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DIDO1 Antibody

  • 货号：
    CSB-PA002147
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using Dio-1 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9BTC0
  • 基因名：
    DIDO1
  • 别名：
    DIDO1 antibody; C20orf158 antibody; DATF1 antibody; KIAA0333Death-inducer obliterator 1 antibody; DIO-1 antibody; hDido1 antibody; Death-associated transcription factor 1 antibody; DATF-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human Dio-1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative transcription factor, weakly pro-apoptotic when overexpressed. Tumor suppressor. Required for early embryonic stem cell development.; Displaces isoform 4 at the onset of differentiation, required for repression of stemness genes.
  • 基因功能参考文献：
    1. Results identified a novel pH-dependent mechanism by which epigenetic reader, the PHD fingers of DIDO, recognize the histone mark H3K4me3. The pH-sensing ability might be necessary for normal biological processes and those characterized by altered cellular pH. PMID: 28919441
    2. evaluated the Death Inducer-Obliterator (DIDO) (variants DIDO 1, 2 and 3) levels in CML, PV, ET and PMF patients. Our data reported the DIDO 1, 2 and 3 differential expressions in Myeloproliferative Neoplasms. PMID: 27282563
    3. Dido1 induces the expression of Integrin alphaV, thereby promoting the attachment, migration, invasion and apoptosis resistance of melanoma cells. PMID: 22469980
    4. Data show that CSE1L, DIDO1 and RBM39 mRNA expression levels correlated with chromosome 20q DNA copy number status. PMID: 22711543
    5. Gambogic acid induces the apoptosis of Raji cells through DIO-1 upregulation, nuclear translocation, Bcl-xL downregulation and caspase 3 activation. PMID: 19236754
    6. Data suggest that Dido might be one of the tumor suppressor genes at chromosome 20q and that the Dido-targeted mouse may be a suitable model for studying myeloproliferative diseases and myelodysplastic syndromes. PMID: 16127461
    7. Dido3, the largest splice variant of the Dido gene, is a centrosome-associated protein whose disruption leads to supernumerary centrosomes, failure to maintain cellular mitotic arrest, and early degradation of the mitotic checkpoint protein BubR1. PMID: 17299043
    8. Gambogic acid induces DIDO1-mediated apoptosis in Jurkat T cells. PMID: 18298900

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2680

    OMIM: 604140

    KEGG: hsa:11083

    STRING: 9606.ENSP00000266070

    UniGene: Hs.517172