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DIAPH3 Antibody

  • 货号：
    CSB-PA006892GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NSV4
  • 基因名：
  • 别名：
    AN antibody; AUNA1 antibody; Dia2 antibody; diap3 antibody; DIAP3_HUMAN antibody; DIAPH3 antibody; Diaphanous homolog 3 (Drosophila) antibody; Diaphanous homolog 3 antibody; Diaphanous related formin 3 antibody; Diaphanous; Drosophila; homolog of; 3 antibody; Diaphanous-related formin-3 antibody; DKFZp434C0931 antibody; DKFZp686A13178 antibody; DRF3 antibody; FLJ34705 antibody; mDia2 antibody; NSDAN antibody; OTTHUMP00000018480 antibody; Protein diaphanous homolog 3 antibody; RP11-26P21.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DIAPH3
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity.
  • 基因功能参考文献：
    1. These data identify Diaph3 as a major guard of cortical progenitors, unravel novel functions of Diaphanous formins and add insights into the pathobiology of microcephaly. PMID: 27848932
    2. study demonstrated the oncogenic activity of DIAPH3 in the progression of hepatocellular carcinoma and suggested that PDIAPH3 might be a therapeutic target. PMID: 28795316
    3. Members of 3 generations of a family had dominant auditory neuropathy associated with a c.-172G>A point mutation in DIAPH3. PMID: 27658576
    4. DIAPH3 overexpression inhibits the migration and invasion of Triple-negative breast cancer by inhibiting RhoA-GTP expression. PMID: 28779705
    5. mDia2 and CXCR4 associate in blebs upon CXCL12 stimulation. Both CXCR4 and RhoA are required for CXCL12-induced blebbing PMID: 28115158
    6. we use a simple cellular system to examine fundamental features of formin-mediated filopodial assembly, using constitutively active constructs of the formins mDia2 and FMNL3 PMID: 26446836
    7. results suggest that inhibition of MT stability arising from DIAPH3 downregulation enhances susceptibility to MT poisons, and that the DIAPH3 network potentially reports taxane sensitivity in human tumors PMID: 26179371
    8. Dia1, Dia2, and Dia3 are involved in ErbB2-dependent capture of microtubules at the cell leading edge and ErbB2-driven guided migration. PMID: 24403606
    9. An mDia2/ROCK signaling axis regulates invasive egress from epithelial ovarian cancer spheroids. PMID: 24587343
    10. TGF-beta promotes association of mDia2 with actin stress fibers, which further drives stress fiber formation and myofibroblast differentiation PMID: 23580645
    11. In human tumours, DIAPH3 down-regulation was associated with aggressive or metastatic disease. PMID: 22593025
    12. isoform-selective actin assembly by DIAPH3 exerts specific and differentially regulated functions during cell adhesion and motility. PMID: 22184005
    13. the amino terminus of mDia2 serves as a coincidence detection module, directing mDia2 to the plasma membrane through interactions with phospholipids and activated Rif PMID: 21119010
    14. These findings reveal a key role for mDia3 and its regulation by Aurora B phosphorylation in achieving proper stable kinetochore microtubule attachment. PMID: 21397845
    15. These studies further suggest that Rho GTPases significantly influence the activity of mDia family formins in driving cellular membrane remodeling through the regulation of actin dynamics. PMID: 17198702
    16. DIP-induced membrane blebbing was dependent on Diaphanous 2 but did not require the activities of either Diaphanous 1 or Actin-Related Protein 2-3 Complex. PMID: 17398099
    17. Data show that Dia2 localizes in the lamella of migrating epithelial cells, where it is involved in the formation of a stable pool of cortical actin and in maintenance of polymerization-competent free filament barbed ends at focal adhesions. PMID: 17855386
    18. Results suggest that WAVE and the Arp2/3 complex jointly orchestrate different types of actin-based plasma membrane protrusions by promoting ruffling and inhibiting mDia2-induced filopodia. PMID: 18516090
    19. active Drf3 lacking the C-terminal regulatory region (Drf3DeltaDAD) induced the formation of filopodia and accumulated at their tips. PMID: 18755006
    20. mDia2 is degraded at the end of mitosis; mDia2 is targeted for disposal by post-translational ubiquitin modification; forced expression of activated mDia2 yields binucleate cells due to failed cytokinesis PMID: 19457867

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  • 相关疾病：
    Auditory neuropathy, autosomal dominant, 1 (AUNA1)
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Formin homology family, Diaphanous subfamily
  • 数据库链接：

    HGNC: 15480

    OMIM: 609129

    KEGG: hsa:81624

    STRING: 9606.ENSP00000383178

    UniGene: Hs.283127