Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. DHX36 Antibody

DHX36 Antibody

  • 货号：
    CSB-PA006878GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9H2U1
  • 基因名：
    DHX36
  • 别名：
    DDX36 antibody; DEAH box protein 36 antibody; Dhx36 antibody; DHX36_HUMAN antibody; EC 3.6.1.- antibody; KIAA1488 antibody; MLE like protein 1 antibody; MLE-like protein 1 antibody; MLEL1 antibody; Probable ATP dependent RNA helicase DHX36 antibody; Probable ATP-dependent RNA helicase DHX36 antibody; RHAU antibody; RNA helicase associated with AU rich element ARE antibody; RNA helicase associated with AU-rich element ARE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DHX36
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA). Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation th...显示更多
  • 基因功能参考文献：
    1. Data show that helicases RHAU, BLM, and WRN exhibit distinct G-quadruplex (GQ) conformation specificity, but use a common mechanism of repetitive unfolding that leads to disrupting GQ structure multiple times in succession. PMID: 27407146
    2. RHAU mediates the unfolding of DNA and RNA quadruplexes. PMID: 28065761
    3. The study provides the first evidence that the unfolding kinetics of a G-quadruplex can be modulated by different nucleotide-bound states of the RHAU helicase. PMID: 28069994
    4. RHAU binds to an adenosine-rich region near the 3'-end of the long non-coding RNA BC200. PMID: 26740632
    5. present a model showing that a replication fork disrupting a T-loop could create a 5' quadruplex with an opened 3'tail structure that is recognized by G4R1 PMID: 26172836
    6. we identify a novel function of DHX36 to facilitate viral RNA recognition PMID: 24651521
    7. Used an integrated approach that includes small angle x-ray scattering, nuclear magnetic resonance spectroscopy, circular dichroism, and dynamic light scattering methods to demonstrate the recognition of G-quadruplexes by the N-terminal domain of RHAU. PMID: 24151078
    8. Data supports a helicase function of RHAU on an intramolecular RNA quadruplex and show that the enzyme is capable of completely converting quadruplex RNA to a stable duplex. PMID: 22238380
    9. Data show that hnRNPA1/A2, HuR and DAZAP1 splicing factors and DHX36 RNA helicase bind to the ISE, with hnRNPA1 acting negatively and DAZAP1 positively on splicing selection PMID: 21858080
    10. The helicase domain of DHX36 does not mediate telomerase RNA (hTR) binding; instead, hTR interacts with the N-terminal accessory domain of DHX36 known to bind specifically to the parallel-strand G-quadruplex substrates resolved by the helicase domain. PMID: 21149580
    11. The amino-terminal region of RHAU is essential for RHAU to bind G4 structures and within this region the evolutionary conserved RSM (RHAU-specific motif) domain is a major affinity and specificity determinant PMID: 20472641
    12. DHX9/DHX36 represent the MyD88-dependent DNA sensors in the cytosol of plasmacytoid dendritic cells and suggest a much broader role for DHX helicases in viral sensing PMID: 20696886
    13. DHX36 protein is responsible for the majority of tetramolecular G4-DNA resolvase activity PMID: 16150737
    14. RHAU has a dual function, being involved in both the synthesis and degradation of mRNA in different subcellular compartments. PMID: 18279852
    15. the RNA quadruplex resolving enzymatic activity associated with G4R1/RHAU and its exceptional binding affinity, suggesting a potential novel role for G4R1/RHAU in targeting in vivo RNA quadruplex structures PMID: 18842585
    16. RHAU is the fourth RNA helicase detected in SGs, after rck/p54, DDX3, and eIF4A, and its association with SGs is dynamic and mediated by an RHAU-specific RNA-binding domain PMID: 18854321

    收起更多

  • 亚细胞定位：
    Nucleus. Cytoplasm. Cytoplasm, cytosol. Cytoplasm, Stress granule. Nucleus speckle. Chromosome, telomere. Mitochondrion. Perikaryon. Cell projection, dendrite. Cell projection, axon.; [Isoform 1]: Nucleus. Cytoplasm.; [Isoform 2]: Nucleus. Cytoplasm.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 14410

    OMIM: 612767

    KEGG: hsa:170506

    STRING: 9606.ENSP00000417078

    UniGene: Hs.446270