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DHX33 Antibody

  • 货号：
    CSB-PA884479LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DHX33 antibody at 16µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 79, 61 kDa
      Observed band size: 79 kDa
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA884479LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA884479LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA884479LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DHX33 Polyclonal antibody
  • Uniprot No.：
    Q9H6R0
  • 基因名：
  • 别名：
    DHX33 antibody; DDX33ATP-dependent RNA helicase DHX33 antibody; EC 3.6.4.13 antibody; DEAH box protein 33 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent RNA helicase DHX33 protein (116-357AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DHX33 Antibody (CSB-PA884479LA01HU)，的标记方式是Non-conjugated。对于DHX33 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884479LB01HU DHX33 Antibody, HRP conjugated ELISA
    FITC CSB-PA884479LC01HU DHX33 Antibody, FITC conjugated
    Biotin CSB-PA884479LD01HU DHX33 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing. Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways.
  • 基因功能参考文献：
    1. DHX33 doublet is due to alternative translation initiation by two in-frame initiation codons. DHX33 translation initiation from either AUG codon happens at equal efficiency. Short DHX33 protein has similar cellular location and functions with full-length DHX33. Leaky scanning normally occurs in DHX33 mRNA translation, which may serve as a safeguard mechanism to ensure optimal DHX33 translation efficiency. PMID: 29864424
    2. In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in hepatocellular carcinoma. PMID: 27693040
    3. High expression of DHX33 is associated with non-Hodgkin's lymphoma and acute myeloid leukemia. PMID: 28498893
    4. Study demonstrates that DHX33 acts as a direct transcriptional regulator to promote cell cycle progression and plays an important role in driving cell proliferation during both embryo development and tumorigenesis. PMID: 27601587
    5. Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease. PMID: 27073163
    6. The results reveal a newly recognized function of DHX33 in mRNA translation initiation, further solidifying its central role in promoting cell growth and proliferation. PMID: 26100019
    7. Data indicate that DHX33 forms the inflammasome complex with NLRP3 following stimulation with cytosolic RNA. PMID: 23871209
    8. results directly implicate DHX33 as a crucial player in establishing rRNA synthesis rates in the face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals. PMID: 23401854
    9. we show the mechanistic importance of DHX33 in rRNA transcription and proliferation PMID: 21930779

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  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Cytoplasm. Nucleus. Inflammasome.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 数据库链接：

    HGNC: 16718

    OMIM: 614405

    KEGG: hsa:56919

    STRING: 9606.ENSP00000225296

    UniGene: Hs.250456