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  4. DHX29 Antibody

DHX29 Antibody

  • 中文名称：
    DHX29兔多克隆抗体
  • 货号：
    CSB-PA006872GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7Z478
  • 基因名：
    DHX29
  • 别名：
    DHX29 antibody; DDX29ATP-dependent RNA helicase DHX29 antibody; EC 3.6.4.13 antibody; DEAH box protein 29 antibody; Nucleic acid helicase DDXx antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DHX29
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity.
  • 基因功能参考文献：
    1. A critical role for DHX29 in innate immune response; molecular insights into the mechanisms by which DHX29 recognizes 5' structured EMCV RNA and interacts with MDA5 for potent type I interferon signaling and antiviral immunity. PMID: 29462185
    2. DHX29 and eIF3 cooperate in scanning on structured mRNAs. Our findings support previous genetic data on the role of eIF3 during scanning PMID: 27733651
    3. DHX29 is another example of an initiation factor contributing to start codon selection. PMID: 27067542
    4. Helicase proteins DHX29 and RIG-I cosense cytosolic nucleic acids in the human airway system. PMID: 24821782
    5. Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs. PMID: 23047696
    6. Down-regulation of DHX29 leads to impaired translation, resulting in disassembly of polysomes and accumulation of mRNA-free 80S monomers. DHX29 depletion also impedes cancer cell growth in culture and in xenografts. PMID: 20018725
    7. Study reports that these 7 eIFs are not sufficient for efficient 48S complex formation on mRNAs with highly structured 5'UTRs, and that this process requires the DExH-box protein DHX29. PMID: 19109895

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily
  • 数据库链接：

    HGNC: 15815

    OMIM: 612720

    KEGG: hsa:54505

    STRING: 9606.ENSP00000251636

    UniGene: Hs.593268