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DHX15 Antibody

  • 货号：
    CSB-PA006870LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate
      All lanes: DHX15 antibody at 3.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 91 kDa
      Observed band size: 91 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DHX15 Polyclonal antibody
  • Uniprot No.：
    O43143
  • 基因名：
    DHX15
  • 别名：
    ATP dependent RNA helicase #46 antibody; ATP-dependent RNA helicase #46 antibody; DBP1 antibody; DDX15 antibody; DEADH box 15 antibody; DEAH (Asp Glu Ala His) box polypeptide 15 antibody; DEAH box polypeptide 15 antibody; DEAH box protein 15 antibody; DHX15 antibody; DHX15_HUMAN antibody; HRH2 antibody; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 antibody; PRP43 antibody; PrPp43p antibody; RNA helicase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 protein (371-502AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DHX15 Antibody (CSB-PA006870LA01HU)，的标记方式是Non-conjugated。对于DHX15 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006870LB01HU DHX15 Antibody, HRP conjugated ELISA
    FITC CSB-PA006870LC01HU DHX15 Antibody, FITC conjugated
    Biotin CSB-PA006870LD01HU DHX15 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns.
  • 基因功能参考文献：
    1. DHX15 regulates androgen receptor (AR) activity by modulating E3 ligase Siah2-mediated AR ubiquitination independent of its ATPase activity promoting prostate cancer progression. PMID: 28991234
    2. The crystal structure of human DHX15 reveals a domain organization of the mammalian DEAH/RHA family. PMID: 28580923
    3. Loss of DHX15 expression is associated with glioma. PMID: 28829764
    4. depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step. PMID: 28115624
    5. Mutation in DHX15 is associated with core-binding factor acute myeloid leukemia. PMID: 27798625
    6. Data indicate that DEAH-box RNA helicase DHX15/PRP43 stimulates the NF-kappaB and MAPK pathways downstream of virus-induced signaling adapter protein MAVS and contributes to MAVS-mediated cytokine production and apoptosis. PMID: 24782566
    7. The results suggest that activation of Prp43p by Gno1p/PINX1 within early pre-ribosomal particles is crucial for their subsequent maturation. PMID: 24823796
    8. Data suggest that G-patch domain of RBM5 is indispensable for its ability to interact with DHX15; RBM5 stimulates helicase activity of DHX15 in a G-patch domain-dependent manner. PMID: 22569250

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  • 亚细胞定位：
    Nucleus. Nucleus, nucleolus.
  • 蛋白家族：
    DEAD box helicase family, DEAH subfamily, DDX15/PRP43 sub-subfamily
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 2738

    OMIM: 603403

    KEGG: hsa:1665

    STRING: 9606.ENSP00000336741

    UniGene: Hs.696074