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DHTKD1 Antibody

  • 货号：
    CSB-PA842685ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DHTKD1 antibody at 1.82µg/ml
      Lane 1: Mouse heart tissue
      Lane 2: A431 whole cell lysate
      Lane 3: MCF-7 whole cell lysate
      Lane 4: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 103 kDa
      Observed band size: 103 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA842685ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA842685ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DHTKD1 Polyclonal antibody
  • Uniprot No.：
    Q96HY7
  • 基因名：
    DHTKD1
  • 别名：
    AMOXAD antibody; CMT2Q antibody; Dehydrogenase E1 and transketolase domain containing 1 antibody; Dehydrogenase E1 and transketolase domain containing protein 1 antibody; Dehydrogenase E1 and transketolase domain-containing protein 1 antibody; DHTK1_HUMAN antibody; dhtkd1 antibody; DKFZp762M115 antibody; KIAA1630 antibody; MGC3090 antibody; Probable 2 oxoglutarate dehydrogenase E1 component DHKTD1 mitochondrial antibody; Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial protein (1-280AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).
  • 基因功能参考文献：
    1. DHTKD1 encodes the E1 subunit of the alpha-ketoadipic acid dehydrogenase complex PMID: 25860818
    2. DHTKD1 contributes to mitochondrial biogenesis and function maintenance. PMID: 24076469
    3. DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria. PMID: 23141293
    4. A nonsense mutation in DHTKD1 causes Charcot-Marie-Tooth disease type 2 in a large Chinese pedigree. PMID: 23141294
  • 相关疾病：
    Charcot-Marie-Tooth disease 2Q (CMT2Q); 2-aminoadipic 2-oxoadipic aciduria (AMOXAD)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Alpha-ketoglutarate dehydrogenase family
  • 数据库链接：

    HGNC: 23537

    OMIM: 204750

    KEGG: hsa:55526

    STRING: 9606.ENSP00000263035

    UniGene: Hs.104980