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DGKQ Antibody

  • 货号：
    CSB-PA007638
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HT-29 cells using DGK-θ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P52824
  • 基因名：
  • 别名：
    DAG kinase theta antibody; DAGK4 antibody; DAGK7 antibody; DGK theta antibody; DGK-theta antibody; Dgkq antibody; DGKQ_HUMAN antibody; Diacylglycerol kinase delta (110kD) antibody; Diacylglycerol kinase theta 110kDa antibody; Diacylglycerol kinase theta antibody; Diglyceride kinase theta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human DGK-θ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis.
  • 基因功能参考文献：
    1. these data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells PMID: 24369117
    2. The SF1 and SREBP1 activate DGKtheta; transcription in a cAMP-dependent manner in human adrenocortical cells. PMID: 23610160
    3. This study found that the minor alleles of GAK rs1564282 and DGKQ rs11248060 significantly increase the risk of PD in Han Chinese populations. PMID: 23618683
    4. Data suggest that diacylglycerol kinase theta is a key mediator of bile-acid-stimulated modulation of farnesoid X receptor/mTOR complex 2/Akt signaling pathway and glucose metabolism/homoeostasis in hepatocytes. PMID: 23767959
    5. DGKtheta; translocation and activity is regulated by the concerted activity of EGFR and PKC. PMID: 22732145
    6. DGK-theta; directly interacts with, and is activated by, basic proteins such as histone H1 and Tau with nm affinity, consistent with a potential role for a polybasic protein or protein domain in the activation of this enzyme. PMID: 23091060
    7. Nuclear DGK-theta co-localizes with phosphatidylinositol 4,5-bisphosphate (PIP(2)) in domains that correspond to nuclear speckles. PMID: 12799190
    8. DGK interacts selectively with and is phosphorylated by PKCepsilon and -eta and peptide agonist-induced selective activation of PKCepsilon directly leads to DGK translocation PMID: 15632189

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, cytosol. Cell membrane. Cell junction, synapse. Cytoplasm, cytoskeleton. Nucleus. Nucleus speckle. Nucleus matrix.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 数据库链接：

    HGNC: 2856

    OMIM: 601207

    KEGG: hsa:1609

    STRING: 9606.ENSP00000273814

    UniGene: Hs.584858