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DGKK Antibody

  • 货号：
    CSB-PA006839GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q5KSL6
  • 基因名：
  • 别名：
    DGKKDiacylglycerol kinase kappa antibody; DAG kinase kappa antibody; EC 2.7.1.107 antibody; 142 kDa diacylglycerol kinase antibody; Diglyceride kinase kappa antibody; DGK-kappa antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human DGKK-Specific
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable).
  • 基因功能参考文献：
    1. FMRP is mostly associated diacylglycerol kinase kappa (Dgkkappa), a master regulator that controls the switch between diacylglycerol and phosphatidic acid signaling pathways. PMID: 27233938
    2. Dgkk appears to be a marker or mediator of squamous cell differentiation in development of mouse external genitalia. No association exists between Dgkk expression and formation of preputial cleft in the genital tubercle of diethylsilbestrol treated mice. PMID: 26162297
    3. Studied the relationship between DGKK single nucleotide polymorphisms (SNPs) and hypospadias risk in the Han Chinese population. PMID: 25327554
    4. Common variants in DGKK are strongly associated with risk of hypospadias PMID: 21113153
    5. DGK kappa is a novel human type II diacylglycerol kinase PMID: 16210324

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  • 亚细胞定位：
    Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    Expressed in testis, and to a lesser extent in placenta.
  • 数据库链接：

    HGNC: 32395

    OMIM: 300837

    KEGG: hsa:139189

    UniGene: Hs.38132