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DGKH Antibody

  • 货号：
    CSB-PA054492
  • 规格：
    ￥2024
  • 图片：
    • Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using DGKH antibody.
    • Immunofluorescence analysis of HeLa cells, using DGKH antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DGKH Polyclonal antibody
  • Uniprot No.：
    Q86XP1
  • 基因名：
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from internal of Human DGKH.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC,IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Plays a key role in promoting cell growth. Activates the Ras/B-Raf/C-Raf/MEK/ERK signaling pathway induced by EGF. Regulates the recruitment of RAF1 and BRAF from cytoplasm to membranes and their heterodimerization.
  • 基因功能参考文献：
    1. This sstudy shown that the highest expression levels of DGKH in the human brain were found in the striatum. PMID: 27085324
    2. DGKH is a replicated risk gene of bipolar disorder (BD). PMID: 27016658
    3. several single variants and genes showed strong association with Panic Disorders, where DGKH was found to be the strongest Panic Disorder associated gene. Interestingly DGKH has previously demonstrated genome-wide significant association with bipolar disorder as well as evidence of association to other mental disorders. PMID: 27255576
    4. DGKeta-Pleckstrin Homology Domain preferentially interacts with Phosphatidylinositol 4,5-Bisphosphate and has crucial roles in regulating the subcellular localization and physiological function of DGKeta. PMID: 26887948
    5. This study demonstrated that significant association of the DGKH risk haplotype with increased amygdala volume in Bipolar disorder, but not in schizophreia or healthy controls. PMID: 24958494
    6. These findings implicate a link between nucleotide variant of DGKH and a cause for a complex-trait disease, calcium oxalate stone PMID: 25081328
    7. DGKK variants are associated with hypospadias PMID: 23177175
    8. expressions of DGKeta and DGKzeta were increased and decreased, respectively, whereas those of DGKgamma and DGKepsilon remained unchanged. This is the first report that describes the differential regulation of DGK isoforms in normal and failing human hearts. PMID: 21548979
    9. Differential effects of DGKH in healthy controls vs the bipolar high-risk group manifest as a failure to disengage default-mode regions in those at familial risk carrying the risk haplotype. PMID: 22048461
    10. Four DGKH markers are linked to adult attention-hyperactivity disorder and seven to unipolar depression, making DGKH a risk factor gene for bipolar disorder, unipolar depression and adult attention-deficit hyperactivity disorder. PMID: 21654738
    11. Increased gene expression of diacylglycerol kinase eta is found in brain tissue from patients with bipolar disorder. PMID: 20519059
    12. Although the association was not strong, the result of this study would support the association between DGKH and BD. PMID: 21507135
    13. The results of tisd support DGKH as shared risk factor of bipolar disorder and schizophrenia in the Chinese Han population. PMID: 20733578
    14. No significant association after multiple-testing correction between any of the single nucleotide polymorphisms in DGKH and bipolar disorder, was found. PMID: 19478689
    15. While negative, our findings do not exclude an involvement of DGKH and NR1D1 in lithium prophylaxis. PMID: 19818381
    16. alternative splicing of the human DGK eta gene generates at least two isoforms with distinct biochemical and cell biological properties responding to different cellular metabolic requirements PMID: 12810723
    17. diacylglycerol kinase eta (DGKH) is association in the etiology of bipolar disorder. PMID: 17486107
    18. DGKeta acts as a novel critical regulatory component of the Ras/B-Raf/C-Raf/MEK/ERK signaling cascade via a previously unidentified mechanism. PMID: 19710016

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016).
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    [Isoform 1]: Expressed only in testis, kidney and colon.; [Isoform 2]: Ubiquitously expressed.
  • 数据库链接：

    HGNC: 2854

    OMIM: 604071

    KEGG: hsa:160851

    STRING: 9606.ENSP00000337572

    UniGene: Hs.630380