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DGKD Antibody

  • 货号：
    CSB-PA002129
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using DGK-δ Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q16760
  • 基因名：
  • 别名：
    DGKD antibody; KIAA0145Diacylglycerol kinase delta antibody; DAG kinase delta antibody; EC 2.7.1.107 antibody; 130 kDa diacylglycerol kinase antibody; Diglyceride kinase delta antibody; DGK-delta antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human DGK-δ.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). By controlling the levels of diacylglycerol, regulates for instance the PKC and EGF receptor signaling pathways and plays a crucial role during development. May also regulate clathrin-dependent endocytosis.
  • 基因功能参考文献：
    1. purification and characterization of DGKepsilon's enzymatic and conformational properties PMID: 28199087
    2. Diacylglycerol signaling limits Akt activation through diacylglycerol kinase delta and PHLPP2. PMID: 23184957
    3. This study demonistrated that the lack of association of DGKD SNPs with PD in the Han Chinese population. PMID: 22406787
    4. Zinc site mutations impair DGKdelta localization to cytoplasmic puncta and enhance localization the plasma membrane. PMID: 20857926
    5. Data indicate a novel mechanism where diacylglycerol kinase delta and protein kinase Calpha modulate the levels of ubiquitinated epidermal growth factor receptors through Akt and ubiquitin-specific protease 8. PMID: 20064931
    6. Alternative splicing of the gene generates two isoforms differing in their expression patterns and in regulatory functions PMID: 12200442
    7. Phosphorylation is involved in the control of subcellular localization of DGKdelta1. PMID: 15228384
    8. Disruption of diacylglycerol kinase delta (DGKD) is associated with seizures in humans and mice. PMID: 17357084
    9. Study identified reduced diacylglycerol kinase delta (DGKdelta) expression and DGK activity in skeletal muscle from type 2 diabetic patients. PMID: 18267070
    10. Polymerization of DGK delta regulates the activity of the enzyme by sequestering DGK delta in an inactive cellular location. PMID: 18334213

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  • 亚细胞定位：
    Membrane, clathrin-coated pit. Cytoplasm.; [Isoform 1]: Cell membrane; Peripheral membrane protein. Cytoplasm.
  • 蛋白家族：
    Eukaryotic diacylglycerol kinase family
  • 组织特异性：
    [Isoform 2]: Widely expressed.; [Isoform 1]: Only detected in ovary, and to a lesser extent in spleen.
  • 数据库链接：

    HGNC: 2851

    OMIM: 601826

    KEGG: hsa:8527

    STRING: 9606.ENSP00000264057

    UniGene: Hs.471675