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DET1 Antibody

  • 货号：
    CSB-PA762572ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA762572ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA762572ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DET1 Polyclonal antibody
  • Uniprot No.：
    Q7L5Y6
  • 基因名：
  • 别名：
    DET1 antibody; DET1 homolog antibody; De-etiolated-1 homolog antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DET1 homolog protein (15-240AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation.
  • 基因功能参考文献：
    1. promotes ubiquitination and degradation of c-Jun by assembling a multisubunit ubiquitin ligase containing DNA Damage Binding Protein-1 (DDB1), cullin 4A (CUL4A), Regulator of Cullins-1 (ROC1), and constitutively photomorphogenic-1 PMID: 14739464
    2. These findings demonstrate that the conserved DET1 complex modulates Cul4A functions by a novel mechanism. PMID: 17452440
  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    DET1 family
  • 组织特异性：
    Highly expressed in the ovary, some lymphoid organs and resting leukocytes.
  • 数据库链接：

    HGNC: 25477

    OMIM: 608727

    KEGG: hsa:55070

    STRING: 9606.ENSP00000408994

    UniGene: Hs.655064