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DENND5A Antibody

  • 货号：
    CSB-PA757108LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA757108LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DENND5A Polyclonal antibody
  • Uniprot No.：
    Q6IQ26
  • 基因名：
    DENND5A
  • 别名：
    DENND5A antibody; KIAA1091 antibody; RAB6IP1DENN domain-containing protein 5A antibody; Rab6-interacting protein 1 antibody; Rab6IP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DENN domain-containing protein 5A protein (1-300AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DENND5A Antibody (CSB-PA757108LA01HU)，的标记方式是Non-conjugated。对于DENND5A Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA757108LB01HU DENND5A Antibody, HRP conjugated ELISA
    FITC CSB-PA757108LC01HU DENND5A Antibody, FITC conjugated
    Biotin CSB-PA757108LD01HU DENND5A Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth.
  • 基因功能参考文献：
    1. identification of an epileptic encephalopathy additionally featuring cerebral calcifications and coarse facial features caused by recessive loss-of-function mutations in DENND5A PMID: 27866705
    2. A RUN Domain from DENND5/Rab6IP1 binds sorting Nexin 1 and is involved in the trafficking of vesicles at the level of Golgi. PMID: 22558185
    3. crystal structure of Rab6a(GTP) in complex with a 378-residue internal fragment of the effector Rab6IP1 was solved at 3.2 angstroms resolution. This Rab6IP1 region encompasses an all alpha-helical RUN domain followed in tandem by a PLAT domain PMID: 19141279
  • 相关疾病：
    Epileptic encephalopathy, early infantile, 49 (EIEE49)
  • 亚细胞定位：
    Golgi apparatus membrane.
  • 蛋白家族：
    RAB6IP1 family
  • 数据库链接：

    HGNC: 19344

    OMIM: 617278

    KEGG: hsa:23258

    STRING: 9606.ENSP00000328524

    UniGene: Hs.501857