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DENND2D Antibody

  • 货号：
    CSB-PA887987LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: DENND2D antibody at 4µg/ml + MCF-7 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA887987LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DENND2D Polyclonal antibody
  • Uniprot No.：
    Q9H6A0
  • 基因名：
    DENND2D
  • 别名：
    2010308M01Rik antibody; AI451421 antibody; DEN2D_HUMAN antibody; DENN domain containing 2D antibody; DENN domain-containing protein 2D antibody; DENN/MADD domain containing 2D antibody; DENND2D antibody; FLJ22457 antibody; MGC6915 antibody; RGD1305120 antibody; RP5-1180E21.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DENN domain-containing protein 2D protein (1-233AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DENND2D Antibody (CSB-PA887987LA01HU)，的标记方式是Non-conjugated。对于DENND2D Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA887987LB01HU DENND2D Antibody, HRP conjugated ELISA
    FITC CSB-PA887987LC01HU DENND2D Antibody, FITC conjugated
    Biotin CSB-PA887987LD01HU DENND2D Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.
  • 基因功能参考文献：
    1. resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D) PMID: 27929118
    2. Higher frequency of promoter hypermethylation of DENND2D is associated with gastric cancer. PMID: 24695972
    3. DENND2D is a candidate tumor suppressor gene that was inactivated by promoter hypermethylation in patients with esophageal squamous cell carcinoma and may serve as a novel biomarker of esophageal squamous cell carcinoma. PMID: 24317529
    4. DENND2D is a candidate tumor suppressor gene that is inactivated by promoter hypermethylation in patients with Hepatocellular carcinoma and may serve as a novel biomarker of early recurrence of Hepatocellular carcinoma . PMID: 24189587
    5. Our data show that DENND2D might function as a tumor suppressor-like gene, preventing survival and expansion of cells with genetic damage through apoptosis mechanism. Absence of DENND2D might play a permissive role, as an early event, in tumorigenesis. PMID: 23182661
    6. Mutations in DENND2D in melanoma by inhibition of nonsense-mediated mRNA decay. PMID: 18677770

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  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    In bronchial mucosa, mainly expressed in ciliated and basal epithelial cells and weakly in alveolar cells (at protein level). Tends to be down-regulated in lung cancers, immortalized bronchial epithelial cell lines and precancerous lesions.
  • 数据库链接：

    HGNC: 26192

    OMIM: 615111

    KEGG: hsa:79961

    STRING: 9606.ENSP00000350266

    UniGene: Hs.557850