DEFB126 Antibody
产品详情
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产品名称:Rabbit anti-Homo sapiens (Human) DEFB126 Polyclonal antibody
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Uniprot No.:Q9BYW3
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基因名:DEFB126
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别名:DEFB126 antibody; C20orf8 antibody; DEFB26Beta-defensin 126 antibody; Beta-defensin 26 antibody; DEFB-26 antibody; Defensin antibody; beta 126 antibody; Epididymal secretory protein 13.2 antibody; ESP13.2 antibody; HBD26 antibody
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宿主:Rabbit
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反应种属:Human
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免疫原:Recombinant Human Beta-defensin 126 protein (36-111AA)
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免疫原种属:Homo sapiens (Human)
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标记方式:Non-conjugated
本页面中的产品,DEFB126 Antibody (CSB-PA866323LA01HU),的标记方式是Non-conjugated。对于DEFB126 Antibody,我们还提供其他标记。见下表:
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克隆类型:Polyclonal
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抗体亚型:IgG
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纯化方式:>95%, Protein G purified
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浓度:It differs from different batches. Please contact us to confirm it.
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保存缓冲液:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
产品提供形式:Liquid
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应用范围:ELISA, IHC
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推荐稀释比:
Application Recommended Dilution IHC 1:20-1:200 -
Protocols:
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储存条件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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货期:Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
相关产品
靶点详情
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功能:Highly glycosylated atypical beta-defensin involved in several aspects of sperm function. Facilitates sperm transport in the female reproductive tract and contributes to sperm protection against immunodetection; both functions are probably implicating the negative surface charge provided by its O-linked oligosaccharides in the sperm glycocalyx. Involved in binding of sperm to oviductal epithelial cells to form a sperm reservoir until ovulation. Release from the sperm surface during capacitation and ovaluation by an elevation of oviductal fluid pH is unmasking other surface compone...显示更多
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基因功能参考文献:
- Data indicate a significant contribution of the frame-shift polymorphism of defensin beta 126 (DEFB126) rs11467497 to male infertility. PMID: 25721098
- These results demonstrate that the DEFB126 core peptide has critical functions in parallel to its C-terminal tail by showing LPS-binding activity, anti-inflammatory effects and intracellular regulatory function. In addition, DEFB126 displays antimicrobial activity against E. coli, S. aureus, and C. elegans. PMID: 23229569
- This review shows how DEFB126 is critical for efficient transport of sperm in the female reproductive tract, preventing their recognition by the female immune system. PMID: 22710670
- DEFB126 genotype and lectin binding were correlated with sperm performance in the penetration assays. PMID: 21775668
- Analyses restricted to glioblastoma (n = 254) yielded significant associations for the SELP, DEFB126/127, SERPINI1, and LY96 genetic regions. PMID: 19423540
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相关疾病:May be involved in infertility. Homozygosity for frameshift truncating mutations are associated with reduced sperm O-linked glycan content, impaired sperm mobility and a reduced live birth rate (PubMed:21775668, PubMed:25721098). However, for one common mutation the change in sperm sialic acid levels has been challenged (PubMed:26832966).
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亚细胞定位:Secreted.
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蛋白家族:Beta-defensin family
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组织特异性:High-level and epididymis-specific expression. Expression is down-regulated in infertile men.
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数据库链接:
HGNC: 15900
KEGG: hsa:81623
STRING: 9606.ENSP00000371835
UniGene: Hs.124211