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DEDD2 Antibody

  • 货号：
    CSB-PA006649GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q8WXF8
  • 基因名：
    DEDD2
  • 别名：
    DEDD2 antibody; FLAME3 antibody; PSEC0004DNA-binding death effector domain-containing protein 2 antibody; DED-containing protein FLAME-3 antibody; FADD-like anti-apoptotic molecule 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DEDD2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
  • 基因功能参考文献：
    1. FLAME-3 forms nuclear complexes with the TFIIIC102 subunit of human transcription factor IIIC PMID: 11965497
    2. DEDD and DEDD2 may be important mediators for death receptors and that they may target caspases to the nucleus. PMID: 12527898
  • 亚细胞定位：
    Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli.
  • 组织特异性：
    Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell l
  • 数据库链接：

    HGNC: 24450

    KEGG: hsa:162989

    STRING: 9606.ENSP00000470082

    UniGene: Hs.515432