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DECR1 Antibody

  • 货号：
    CSB-PA040684
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA040684(DECR1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-4: Human endometrial carcinoma tissue, Human colon cancer tissue, mouse heart tissue, PC3 cells, Primary antibody: CSB-PA040684(DECR1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q16698
  • 基因名：
    DECR1
  • 别名：
    1200012F07Rik antibody; 2 antibody; 2,4 dienoyl CoA reductase [NADPH] antibody; 2,4 dienoyl CoA reductase 1 antibody; 2,4 dienoyl CoA reductase mitochondrial antibody; 2,4-dienoyl-CoA reductase; mitochondrial antibody; 4 enoyl CoA reductase antibody; 4-dienoyl-CoA reductase [NADPH] antibody; 4-enoyl-CoA reductase [NADPH] antibody; DECR 1 antibody; DECR antibody; DECR_HUMAN antibody; DECR1 antibody; Nadph antibody; OTTMUSP00000004962 antibody; RP23-338J24.3 antibody; SDR18C1 antibody; Short chain dehydrogenase/reductase family 18C member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human DECR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in mitochondria. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA.
  • 基因功能参考文献：
    1. Our study is the first to demonstrate the novel function of UA in NET formation and may provide insight into the management of patients with hyperuricemia. PMID: 24326071
    2. Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase PMID: 15531764
    3. Sequence alignment indicates that there are five highly conserved acidic residues, one of which (E276) might act as a proton donor. PMID: 15629123
    4. mutational defects cause chronic granulomatous disease in humans PMID: 18193341
    5. The luminal NADPH pool is an important antiapoptotic factor in neutrophil granulocytes. PMID: 18472006
    6. The TT genotype of C677T polymorphism in the MTHFR gene contributes to genetic susceptibility of acute ischemic stroke in a Singapore population. PMID: 19049547

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  • 相关疾病：
    2,4-dienoyl-CoA reductase deficiency (DECRD)
  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family, 2,4-dienoyl-CoA reductase subfamily
  • 组织特异性：
    Heart = liver = pancreas > kidney >> skeletal muscle = lung.
  • 数据库链接：

    HGNC: 2753

    OMIM: 222745

    KEGG: hsa:1666

    STRING: 9606.ENSP00000220764

    UniGene: Hs.492212