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DDX42 Antibody

  • 货号：
    CSB-PA773053LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA773053LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA773053LA01HU at dilution of 1:100
    • Immunofluorescence staining of Hela cells cells with CSB-PA773053LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DDX42 Polyclonal antibody
  • Uniprot No.：
    Q86XP3
  • 基因名：
    DDX42
  • 别名：
    DDX42ATP-dependent RNA helicase DDX42 antibody; EC 3.6.4.13 antibody; DEAD box protein 42 antibody; RNA helicase-like protein antibody; RHELP antibody; RNA helicase-related protein antibody; RNAHP antibody; SF3b DEAD box protein antibody; Splicing factor 3B-associated 125 kDa protein antibody; SF3b125 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human ATP-dependent RNA helicase DDX42 protein (519-819AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DDX42 Antibody (CSB-PA773053LA01HU)，的标记方式是Non-conjugated。对于DDX42 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA773053LB01HU DDX42 Antibody, HRP conjugated ELISA
    FITC CSB-PA773053LC01HU DDX42 Antibody, FITC conjugated
    Biotin CSB-PA773053LD01HU DDX42 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
  • 基因功能参考文献：
    1. characterization of protein associated with the human 17S U2 snRNP and one of its stable subunits, SF3b; may facilitate the assembly of the 17S U2 snRNP PMID: 12234937
    2. Ddx42p represents the first example of a human DEAD box protein possessing RNA helicase, protein displacement and RNA annealing activities. PMID: 16397294
    3. expression of N-terminal DDX42 is able to overcome Japanese encephalitis virus-induced antagonism of IFN responses and so may be important for Japanese encephalitis virus pathogenesis PMID: 18588927
  • 亚细胞定位：
    Cytoplasm. Nucleus speckle. Nucleus, Cajal body. Note=Isoform 2 is present in Cajal bodies (CBs) and nuclear speckles.
  • 蛋白家族：
    DEAD box helicase family, DDX42 subfamily
  • 组织特异性：
    Expressed in several cell lines (at protein level). Expressed in liver, lung, tonsil, thymus, muscle and pancreatic islets.
  • 数据库链接：

    HGNC: 18676

    OMIM: 613369

    KEGG: hsa:11325

    STRING: 9606.ENSP00000374574

    UniGene: Hs.702010