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DDX23 Antibody

  • 中文名称：
    DDX23兔多克隆抗体
  • 货号：
    CSB-PA006613GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BUQ8
  • 基因名：
    DDX23
  • 别名：
    100 kDa U5 snRNP-specific protein antibody; DDX23 antibody; DDX23_HUMAN antibody; DEAD box protein 23 antibody; EC 3.6.1.- antibody; Probable ATP-dependent RNA helicase DDX23 antibody; PRP28 homolog antibody; U5-100kD antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DDX23
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA.
  • 基因功能参考文献：
    1. These data provide new insights into the function of Prp28 in higher eukaryotes, and the requirements for stable tri-small nuclear ribonucleoproteins binding during B complex formation. PMID: 27377154
    2. new basis of DDX23-Linc00630-HDAC1 signal axis for understanding its pathogenicity, which could be further developed as a valuable therapeutic strategy PMID: 28473661
    3. pausing of RNA polymerase II (RNA Pol II) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (SRPK2) phosphorylates the DDX23 helicase, culminating in the suppression of R-loops. PMID: 28076779
    4. SRPK2 knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri-snRNP. PMID: 18425142
  • 亚细胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    DEAD box helicase family, DDX23/PRP28 subfamily
  • 数据库链接：

    HGNC: 17347

    OMIM: 612172

    KEGG: hsa:9416

    STRING: 9606.ENSP00000310723

    UniGene: Hs.130098