DDC Antibody

1. We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK, INPP1, DDC, and NPY genes are the most fundamental hubs in the network PMID: 29381655
2. IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with IKZF1 rs11978267 or rs7789635, DDC rs3779084; rs880028; rs7809758, CDKN2A rs3731217, CEBPE rs2239633; rs12434881 PMID: 28768142
3. The data provide evidence for cis-acting, functional common polymorphisms in the DOPA decarboxylase gene in the human ventral striatum. PMID: 26924680
4. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
5. Newborn screening of AADC deficiency was achieved with a 100% positive-predictive rate. An association for gestational age could be further elucidated. PMID: 27216367
6. SNP rs10499695 located intronically in the gene DDC, (DOPA decarboxylase) is significantly associated with cognitive performance in diabetes 2. PMID: 27066308
7. Molecular characteristic and physiological role of DOPA-decarboxylase is reviewed. PMID: 28100850
8. We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro PMID: 27658936
9. The results of this study showed that Lack of Association Between Polymorphisms in Dopa decarboxylase Genes With Childhood PMID: 26337060
10. The data showed that L-DOPA decarboxylase constitutes a highly promising molecular marker for renal cell carcinoma. PMID: 25721989
11. gene study of 987 BPD cases and 1110 healthy controls found an association between BPD [ borderline personality disorder ]and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene PMID: 25017620
12. Results revealed the general picture of structural and/or functional effects of each DDC mutation linked to AADC deficiency mutations and help to guide therapeutic decision and prevent inappropriate use of treatment regiments. PMID: 24865461
13. A novel homozygous DDC variant in syndromic intellectual disability patients, c.1123C>T, resulting in p.Arg375Cys missense substitution. PMID: 25597765
14. Results indicate that miR-145 has the ability to regulate DDC mRNA expression and potentially this occurs by recognizing its mRNA as a target. PMID: 25445287
15. Our results suggest that DDC may be a genetic modifier of the l-dopa response in Parkinson's disease PMID: 24216088
16. 8 SNPs in DDC gene showed significant associations with MaxDrinks. PMID: 23953852
17. Common allelic variants in the DDC gene may be involved in autism susceptibility. PMID: 22397633
18. The data of this study confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. PMID: 24411733
19. Absorbance and fluorescence titrations of hDDC-bound coenzyme identify a single pK(spec) of ~7.2. PMID: 23781496
20. This study provides the first evidence for the involvement of the DDC gene in alerting attention PMID: 23276884
21. The aim of the current study was to analyze the DDC mRNA expression in head and neck squamous cell carcinoma (HNSCC) patients. DDC mRNA levels were lower in squamous cell carcinomas of the larynx and tongue than in adjacent non-cancerous tissue specimens. PMID: 23083099
22. This work is the first to shed light on the potential clinical usefulness of DDC, as an efficient tumor biomarker in gastric cancer. PMID: 23064786
23. This is the first study indicating the potential of DDC expression as a novel prognostic biomarker in patients with PCa who have undergone radical prostatectomy PMID: 22571720
24. In regular smokers, variability at the locus marked by rs3779084 in the dopa decarboxylase gene appears to index biologically based individual differences in the motivation to consume alcohol. PMID: 21797889
25. we report biochemical and bioinformatic analyses of the human wild-type dopa decarboxylase and the pathogenic variants G102S, F309L, S147R and A275T whose mutations concern amino acid residues at or near the active site. PMID: 21541720
26. analysis of how the open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases PMID: 22143761
27. Results describe the cellular topology of active human L-dopa decarboxylase. PMID: 21479916
28. These results suggested that TonEBP played an important role in the epithelial cells of renal proximal tubule upon hypertonic stress by enhancing AAD expression, which could promote dopamine secretion to negative regulate Na+/K+-ATPase activity. PMID: 21982764
29. the human DDC gene undergoes complex processing, leading to the formation of multiple mRNA isoforms in tumor cells PMID: 20535562
30. Normal or increased levels of urinary dopamine are found in the majority of AADC-deficient patientsNormal or increased levels of urinary dopamine are found in the majority of AADC-deficient patients PMID: 20832343
31. The intronic Single Nucleotide Polymorphism at the is significantly associated to the Spielberger State-Trait Anxiety Inventory anxiety scores after multiple testing correction. PMID: 20092830
32. Dopa decarboxylase mRNA expression may be a novel potential tissue biomarker in prognosis of colorectal adenocarcinoma patient survival. PMID: 20424616
33. The expression of enzymatically active DDC shows the endogenous production of dopamine in U937 cells and raises new questions about the enzyme's involvement in immune responses. PMID: 19800137
34. gene promoter directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus. PMID: 11750071
35. findings suggest that the DDC gene is unlikely to play a major role in the development of autism in our data set PMID: 11992572
36. Results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders. PMID: 12116187
37. DDC might confer susceptibility to bipolar affective disorder predominantly when paternally transmitted PMID: 12555230
38. This enzyme is cloned from and expressed in placenta. PMID: 12718431
39. We report three siblings who showed the clinical phenotype to be caused by aromatic L-amino acid decarboxylase deficiency. Molecular characterization showed a homozygous point mutation (c.387 G-->A) in exon 3. PMID: 14991824
40. Polymorphisms studied do not play a major role in paranoid schizophrenia pathogenesis in the population investigated. PMID: 15318031
41. dopamine decarboxylase mRNA in neuroblastoma patients could be a potential marker for minimal residual disease PMID: 15322424
42. Detection of a new alternative splicing event within the coding region of the human dopa decarboxylase (DDC) mRNA, suggests that the single copy human DDC gene undergoes complex processing leading to the formation of multiple mRNA isoforms. PMID: 15532536
43. Single nucleotide polymorphisms in the dopa decarboxylase gene is associated with nicotine dependence PMID: 15879433
44. Immunohistochemical detection of DOPA decarboxylase shows diffuse staining of Langerhans islets in congenital hyperinsulinism. PMID: 16403819
45. association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence PMID: 16740595
46. Association of the DOPA decarboxylase (DDC) gene on chromosome 7p11 with measures of nicotine dependence. PMID: 17184203
47. Autoantibodies to the COOH-terminal region induce a significant inhibition of enzymatic activity. PMID: 17200166
48. Expands clinical spectrum of AADC deficiency and contributes to the knowledge of the genotype and phenotype correlation for the DDC gene. PMID: 17533144
49. The DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0.0017; OR=1.90) PMID: 17938636
50. study does not support the involvement of tyrosine hydroxylase gene variants as major contributors to suicide, whereas dopa decarboxylase variants could mediate some features related to suicide and be involved in violent suicidal behavior PMID: 17948905

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HGNC: 2719

OMIM: 107930

KEGG: hsa:1644

STRING: 9606.ENSP00000350616

UniGene: Hs.359698