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  4. Recombinant Human Aromatic-L-amino-acid decarboxylase (DDC)

Recombinant Human Aromatic-L-amino-acid decarboxylase (DDC)

  • 中文名称：
    Recombinant Human Aromatic-L-amino-acid decarboxylase(DDC),Yeast
  • 货号：
    CSB-YP006583HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Human Aromatic-L-amino-acid decarboxylase(DDC),Yeast
  • 货号：
    CSB-EP006583HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Human Aromatic-L-amino-acid decarboxylase(DDC),Yeast
  • 货号：
    CSB-EP006583HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Human Aromatic-L-amino-acid decarboxylase(DDC),Yeast
  • 货号：
    CSB-BP006583HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Human Aromatic-L-amino-acid decarboxylase(DDC),Yeast
  • 货号：
    CSB-MP006583HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    DDC
  • Uniprot No.：
  • 别名：
    AADC; Aromatic L Amino Acid Decarboxylase; Aromatic-L-amino-acid decarboxylase; DDC; DDC_HUMAN; DOPA decarboxylase (aromatic L-amino acid decarboxylase); DOPA decarboxylase
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-480
  • 氨基酸序列
    MNASEFRRRG KEMVDYMANY MEGIEGRQVY PDVEPGYLRP LIPAAAPQEP DTFEDIINDV EKIIMPGVTH WHSPYFFAYF PTASSYPAML ADMLCGAIGC IGFSWAASPA CTELETVMMD WLGKMLELPK AFLNEKAGEG GGVIQGSASE ATLVALLAAR TKVIHRLQAA SPELTQAAIM EKLVAYSSDQ AHSSVERAGL IGGVKLKAIP SDGNFAMRAS ALQEALERDK AAGLIPFFMV ATLGTTTCCS FDNLLEVGPI CNKEDIWLHV DAAYAGSAFI CPEFRHLLNG VEFADSFNFN PHKWLLVNFD CSAMWVKKRT DLTGAFRLDP TYLKHSHQDS GLITDYRHWQ IPLGRRFRSL KMWFVFRMYG VKGLQAYIRK HVQLSHEFES LVRQDPRFEI CVEVILGLVC FRLKGSNKVN EALLQRINSA KKIHLVPCHL RDKFVLRFAI CSRTVESAHV QRAWEHIKEL AADVLRAERE
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
  • 基因功能参考文献：
    1. We found the suicide-associated gene coexpression network. The reconstructed network consisted of 104 genes. Topological analysis showed that in total, CCK, INPP1, DDC, and NPY genes are the most fundamental hubs in the network PMID: 29381655
    2. IKZF1 rs10235796 C allele, IKZF1 rs6964969A>G, CDKN2A rs3731246 G>C, and CDKN2A rs3731246 C allele were signi fi cantly associated with Acute Lymphoblastic Leukemia in Yemenis of Arab-Asian descent. Borderline association found in IKZF1 rs4132601 T>G variant. No associations found with IKZF1 rs11978267 or rs7789635, DDC rs3779084; rs880028; rs7809758, CDKN2A rs3731217, CEBPE rs2239633; rs12434881 PMID: 28768142
    3. The data provide evidence for cis-acting, functional common polymorphisms in the DOPA decarboxylase gene in the human ventral striatum. PMID: 26924680
    4. Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. This review summarizes the analogies and differences in their origin as well as their common pathophysiological scenarios. [review] PMID: 27769832
    5. Newborn screening of AADC deficiency was achieved with a 100% positive-predictive rate. An association for gestational age could be further elucidated. PMID: 27216367
    6. SNP rs10499695 located intronically in the gene DDC, (DOPA decarboxylase) is significantly associated with cognitive performance in diabetes 2. PMID: 27066308
    7. Molecular characteristic and physiological role of DOPA-decarboxylase is reviewed. PMID: 28100850
    8. We found that only the modified U1 snRNA (IVS-AAA) that completely matched both the intronic and exonic U1 binding sequences of the mutated DDC gene could correct splicing errors of either the mutated human DDC minigene or the mouse artificial splicing construct in vitro PMID: 27658936
    9. The results of this study showed that Lack of Association Between Polymorphisms in Dopa decarboxylase Genes With Childhood PMID: 26337060
    10. The data showed that L-DOPA decarboxylase constitutes a highly promising molecular marker for renal cell carcinoma. PMID: 25721989
    11. gene study of 987 BPD cases and 1110 healthy controls found an association between BPD [ borderline personality disorder ]and single nucleotide polymorphism rs12718541 in the dopa decarboxylase gene PMID: 25017620
    12. Results revealed the general picture of structural and/or functional effects of each DDC mutation linked to AADC deficiency mutations and help to guide therapeutic decision and prevent inappropriate use of treatment regiments. PMID: 24865461
    13. A novel homozygous DDC variant in syndromic intellectual disability patients, c.1123C>T, resulting in p.Arg375Cys missense substitution. PMID: 25597765
    14. Results indicate that miR-145 has the ability to regulate DDC mRNA expression and potentially this occurs by recognizing its mRNA as a target. PMID: 25445287
    15. Our results suggest that DDC may be a genetic modifier of the l-dopa response in Parkinson's disease PMID: 24216088
    16. 8 SNPs in DDC gene showed significant associations with MaxDrinks. PMID: 23953852
    17. Common allelic variants in the DDC gene may be involved in autism susceptibility. PMID: 22397633
    18. The data of this study confirm histidine decarboxylase deficiency as a rare cause of TS and identify HA-DA interactions in the basal ganglia as an important locus of pathology. PMID: 24411733
    19. Absorbance and fluorescence titrations of hDDC-bound coenzyme identify a single pK(spec) of ~7.2. PMID: 23781496
    20. This study provides the first evidence for the involvement of the DDC gene in alerting attention PMID: 23276884
    21. The aim of the current study was to analyze the DDC mRNA expression in head and neck squamous cell carcinoma (HNSCC) patients. DDC mRNA levels were lower in squamous cell carcinomas of the larynx and tongue than in adjacent non-cancerous tissue specimens. PMID: 23083099
    22. This work is the first to shed light on the potential clinical usefulness of DDC, as an efficient tumor biomarker in gastric cancer. PMID: 23064786
    23. This is the first study indicating the potential of DDC expression as a novel prognostic biomarker in patients with PCa who have undergone radical prostatectomy PMID: 22571720
    24. In regular smokers, variability at the locus marked by rs3779084 in the dopa decarboxylase gene appears to index biologically based individual differences in the motivation to consume alcohol. PMID: 21797889
    25. we report biochemical and bioinformatic analyses of the human wild-type dopa decarboxylase and the pathogenic variants G102S, F309L, S147R and A275T whose mutations concern amino acid residues at or near the active site. PMID: 21541720
    26. analysis of how the open conformation of human DOPA decarboxylase reveals the mechanism of PLP addition to Group II decarboxylases PMID: 22143761
    27. Results describe the cellular topology of active human L-dopa decarboxylase. PMID: 21479916
    28. These results suggested that TonEBP played an important role in the epithelial cells of renal proximal tubule upon hypertonic stress by enhancing AAD expression, which could promote dopamine secretion to negative regulate Na+/K+-ATPase activity. PMID: 21982764
    29. the human DDC gene undergoes complex processing, leading to the formation of multiple mRNA isoforms in tumor cells PMID: 20535562
    30. Normal or increased levels of urinary dopamine are found in the majority of AADC-deficient patientsNormal or increased levels of urinary dopamine are found in the majority of AADC-deficient patients PMID: 20832343
    31. The intronic Single Nucleotide Polymorphism at the is significantly associated to the Spielberger State-Trait Anxiety Inventory anxiety scores after multiple testing correction. PMID: 20092830
    32. Dopa decarboxylase mRNA expression may be a novel potential tissue biomarker in prognosis of colorectal adenocarcinoma patient survival. PMID: 20424616
    33. The expression of enzymatically active DDC shows the endogenous production of dopamine in U937 cells and raises new questions about the enzyme's involvement in immune responses. PMID: 19800137
    34. gene promoter directs transgene expression to the adult floor plate and aminergic nuclei induced by the isthmus. PMID: 11750071
    35. findings suggest that the DDC gene is unlikely to play a major role in the development of autism in our data set PMID: 11992572
    36. Results do not support an involvement of the 1-bp or 4-bp deletion within the DDC gene in the etiology of affective disorders. PMID: 12116187
    37. DDC might confer susceptibility to bipolar affective disorder predominantly when paternally transmitted PMID: 12555230
    38. This enzyme is cloned from and expressed in placenta. PMID: 12718431
    39. We report three siblings who showed the clinical phenotype to be caused by aromatic L-amino acid decarboxylase deficiency. Molecular characterization showed a homozygous point mutation (c.387 G-->A) in exon 3. PMID: 14991824
    40. Polymorphisms studied do not play a major role in paranoid schizophrenia pathogenesis in the population investigated. PMID: 15318031
    41. dopamine decarboxylase mRNA in neuroblastoma patients could be a potential marker for minimal residual disease PMID: 15322424
    42. Detection of a new alternative splicing event within the coding region of the human dopa decarboxylase (DDC) mRNA, suggests that the single copy human DDC gene undergoes complex processing leading to the formation of multiple mRNA isoforms. PMID: 15532536
    43. Single nucleotide polymorphisms in the dopa decarboxylase gene is associated with nicotine dependence PMID: 15879433
    44. Immunohistochemical detection of DOPA decarboxylase shows diffuse staining of Langerhans islets in congenital hyperinsulinism. PMID: 16403819
    45. association of alleles and haplotypes at the DOPA decarboxylase (DDC) locus with the DSM-IV diagnosis of nicotine dependence PMID: 16740595
    46. Association of the DOPA decarboxylase (DDC) gene on chromosome 7p11 with measures of nicotine dependence. PMID: 17184203
    47. Autoantibodies to the COOH-terminal region induce a significant inhibition of enzymatic activity. PMID: 17200166
    48. Expands clinical spectrum of AADC deficiency and contributes to the knowledge of the genotype and phenotype correlation for the DDC gene. PMID: 17533144
    49. The DDC gene was strongly associated with both adulthood (P=0.00053; odds ratio (OR)=2.17) and childhood ADHD (P=0.0017; OR=1.90) PMID: 17938636
    50. study does not support the involvement of tyrosine hydroxylase gene variants as major contributors to suicide, whereas dopa decarboxylase variants could mediate some features related to suicide and be involved in violent suicidal behavior PMID: 17948905

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  • 相关疾病：
    Aromatic L-amino-acid decarboxylase deficiency (AADCD)
  • 蛋白家族：
    Group II decarboxylase family
  • 数据库链接：

    HGNC: 2719

    OMIM: 107930

    KEGG: hsa:1644

    STRING: 9606.ENSP00000350616

    UniGene: Hs.359698