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DCUN1D5 Antibody

  • 中文名称：
    DCUN1D5兔多克隆抗体
  • 货号：
    CSB-PA006575GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BTE7
  • 基因名：
    DCUN1D5
  • 别名：
    DCUN1D5DCN1-like protein 5 antibody; DCUN1 domain-containing protein 5 antibody; Defective in cullin neddylation protein 1-like protein 5 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DCUN1D5
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth.
  • 基因功能参考文献：
    1. evidence that DCNL5 may be involved in innate immunity, as it is a direct substrate of the kinase IKKalpha during immune signalling. PMID: 29958295
    2. SCCRO5 has oncogenic potential that requires its function as a component of the neddylation E3. Neddylation activity and nuclear localization of SCCRO5 are important for its in vivo function. PMID: 24192928
    3. Overexpression of DCUN1D5 is associated with laryngeal squamous cell carcinoma. PMID: 23098533
  • 亚细胞定位：
    Nucleus. Cytoplasm, cytoskeleton, spindle.
  • 组织特异性：
    Weakly expressed in testis, skin and immune tissues (thymus, spleen and lymph nodes).
  • 数据库链接：

    HGNC: 28409

    OMIM: 616522

    KEGG: hsa:84259

    STRING: 9606.ENSP00000260247

    UniGene: Hs.503716