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DCTN2 Antibody

  • 货号：
    CSB-PA193732
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from A549 cells, using p50 dynamitin antibody.
    • Western blot analysis of extracts from HuvEc cells (Lane 2), using p50 Dynamitin antiobdy. The lane on the left is treated with synthesized peptide.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DCTN2 Polyclonal antibody
  • Uniprot No.：
    Q13561
  • 基因名：
    DCTN2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human p50 dynamitin.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
  • 基因功能参考文献：
    1. This is the first time a haplotype on chromosome 12 containing sequence variants in the genes DCTN2, DNAH10, LRIG3, and MYO1A has been linked to an inherited neuropathy in humans. PMID: 26517670
    2. dynamitin is involved in the regulation of Nav1.5 cell-surface density PMID: 25088759
    3. the determinants of p50/DM required for self-oligomerization of the protein and for interactions with other subunits of the dynactin complex PMID: 20463029
    4. Altered levels of Cep135 and p50 by RNAi and protein overexpression caused the release of endogenous partner molecules from centrosomes. PMID: 14983524
    5. the Sec23p component of the COPII complex directly interacts with the dynactin complex through the carboxy-terminal cargo-binding domain of p150(Glued). PMID: 15580264
    6. DCTN2 is required in the earliest stages of peroxisome biogenesis. PMID: 15813749
    7. study does not support a major role for DCTN2 overexpression in carcinogenesis PMID: 16369996
    8. Data show how dynamitin's different structural domains contribute to its ability to self-associate, interact with dynactin and assemble into a complex with its close binding partner, p24. PMID: 18182012
    9. The interaction between ZW10 and dynamitin showed that the N-terminal region of ZW10 is the major binding site for dynamitin and, like full-length ZW10, could move along microtubules to the centrosomal area in a dynein-dynactin-dependent manner. PMID: 18782227

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Dynactin subunit 2 family
  • 数据库链接：

    HGNC: 2712

    OMIM: 607376

    KEGG: hsa:10540

    STRING: 9606.ENSP00000408910

    UniGene: Hs.289123