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DBR1 Antibody

  • 货号：
    CSB-PA006529GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UK59
  • 基因名：
  • 别名：
    DBR1 antibody; DBR1_HUMAN antibody; Debranching enzyme homolog 1 (S. cerevisiae) antibody; Lariat debranching enzyme antibody; RNA lariat debranching enzyme antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DBR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.
  • 基因功能参考文献：
    1. findings support a new view of the early steps in HIV genome replication - they support a model in which lariat formation of viral genomic RNA is important for minus-strand transfer, with DBR1 being required to resolve the lariat to allow reverse transcription to proceed PMID: 28931690
    2. Transcriptomic sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the observation that neoplasm is triggered by a decrease in hDBR1 expression both in vitro and in vivo. PMID: 28504715
    3. saturation mutagenesis of DBR1 and Gal4 and show that the experimental phenotypes for over 80% of the mutations correlate well with predicted effects of mutations on protein stability and RNA binding affinity. PMID: 26797105
    4. Results of protein-protein interaction between human Dbr1 and factors found in the Intron Large complex identify Xab2 and a novel protein CWF19L1 as specific interactors of DBR1. PMID: 25671812
    5. Inhibition of DBR1 caused a significant reduction in the formation of intermediate and full-length HIV-1 cDNA. PMID: 24672043
    6. Dbr1 protein cleaves the 2'-5' phosphodiester bond of intron lariats, necessary for subsequent intron degradation that follows pre-mRNA splicing. PMID: 1850323

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Lariat debranching enzyme family
  • 数据库链接：

    HGNC: 15594

    OMIM: 607024

    KEGG: hsa:51163

    STRING: 9606.ENSP00000260803

    UniGene: Hs.477700