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  4. DBNL Antibody

DBNL Antibody

  • 中文名称：
    DBNL兔多克隆抗体
  • 货号：
    CSB-PA006527GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJU6
  • 基因名：
    DBNL
  • 别名：
    ABP1 antibody; Actin-binding protein 1 antibody; Cervical mucin associated protein antibody; Cervical mucin-associated protein antibody; Cervical SH3P7 antibody; CMAP antibody; Dbnl antibody; DBNL_HUMAN antibody; Drebrin F antibody; drebrin like antibody; Drebrin like protein antibody; Drebrin-F antibody; Drebrin-like protein antibody; HIP 55 antibody; HIP-55 antibody; HPK1 interacting protein of 55 kDa antibody; HPK1-interacting protein of 55 kDa antibody; SH3 domain containing protein 7 antibody; SH3 domain-containing protein 7 antibody; SH3P7 antibody; src homology 3 domain containing protein HIP 55 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DBNL
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.
  • 基因功能参考文献：
    1. findings show that mAbp1 and FHL2 are novel binding partners that differentially regulate Rho GTPase signaling and MTLn3 breast cancer cell invasion PMID: 27129278
    2. Data suggest that by binding to both clathrin and F-actin, mammalian actin-binding protein 1 (mAbp1; HIP-55 or SH3P7) is specifically recruited at a late stage of clathrin-coated pits (CCPs) formation, which subsequently recruits dynamin to CCPs. PMID: 25690657
    3. The results presented here indicate that targeting IL-1alpha with subcutaneous MABp1 adminisration has a strong potential therapeutic value in treating psoriasis and may provide a novel future treatment of this often devastating disease. PMID: 25715176
    4. Data indicate that fourteen phosphorylation sites along the primary structure of hematopoietic progenitor kinase 1 (HPK1)-interacting protein of 55 kDa (HIP-55) rotein were identified. PMID: 24651461
    5. HIP-55 expression promoted proliferation, colony formation, migration, and invasion of lung cancer cells and was upregulated in lung cancer cell lines and tumor tissues of lung cancer patients PMID: 24912570
    6. Data suggest that HIP-55 could play an important role in the growth and cellular proliferation and HIP-55 dysfunction could be involved in tumorigenesis. PMID: 24668193
    7. mAbp1 is of fundamental importance for spreading and migration under shear stress conditions, which are critical prerequisites for efficient PMN extravasation during inflammation. PMID: 22450813
    8. substrate for caspase cleavage during apoptosis PMID: 11689006
    9. SH3P7 is essential for endocytosis but not lamellipodia formation. PMID: 12565838
    10. HIP-55 plays a functional role in TCR signaling PMID: 14557276
    11. HIP-55 is a key novel component of the immunological synapse that modulates T cell activation by connecting actin cytoskeleton and TCRs to gene activation and endocytic processes PMID: 14729663
    12. HIP-55 has roles in T-cell proliferation, cytokine production, and immune responses PMID: 16055701
    13. unexpected role of 3BP2 in endocytic and cytoskeletal regulation through its interaction with CIN85 and HIP-55 PMID: 17306257
    14. Filamentous actin (F-actin)-binding protein 1 (Abp1/SH3P7/HIP-55) has a profound impact on synaptic organization by making a required functional connection between postsynaptic density components and postsynaptic actin dynamics. PMID: 18829961

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell junction, synapse. Perikaryon. Cell projection, neuron projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Cell projection, dendrite. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    ABP1 family
  • 数据库链接：

    HGNC: 2696

    OMIM: 610106

    KEGG: hsa:28988

    STRING: 9606.ENSP00000417653

    UniGene: Hs.436500