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DAZ2 Antibody

  • 货号：
    CSB-PA623785ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA623785ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA623785ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DAZ2 Polyclonal antibody
  • Uniprot No.：
    Q13117
  • 基因名：
    DAZ2
  • 别名：
    DAZ2 antibody; DAZ2_HUMAN antibody; DAZ3 antibody; Deleted in azoospermia 2 antibody; Deleted in azoospermia protein 2 antibody; Deleted in azoospermia protein 3 antibody; MGC126442 antibody; pDP1678 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Deleted in azoospermia protein 2 protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  • 基因功能参考文献：
    1. study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population PMID: 27457284
    2. There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. PMID: 23512232
    3. Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility. PMID: 24878370
    4. DAZ gene copy number in severely idiopathic infertile men. Gene deletion of two copies of DAZ (DAZI and 2) was the cause of spermatogenic damage. PMID: 11883873
  • 相关疾病：
    Spermatogenic failure Y-linked 2 (SPGFY2)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
  • 蛋白家族：
    RRM DAZ family
  • 组织特异性：
    Testis specific.
  • 数据库链接：

    HGNC: 15964

    OMIM: 400026

    KEGG: hsa:57055

    STRING: 9606.ENSP00000371870

    UniGene: Hs.592257