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DAND5 Antibody

  • 货号：
    CSB-PA850835LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA850835LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA850835LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) DAND5 Polyclonal antibody
  • Uniprot No.：
    Q8N907
  • 基因名：
    DAND5
  • 别名：
    BMP antagonist 3 antibody; CER2 antibody; cerberus 2 antibody; Cerberus like 2 antibody; Cerberus-like protein 2 antibody; Cerl-2 antibody; CERL2 antibody; CKTSF1B3 antibody; COCO antibody; CRL2 antibody; Cysteine knot superfamily 1 antibody; Cysteine knot superfamily 1 BMP antagonist 3 antibody; DAN domain family member 5 antibody; Dand5 antibody; DAND5_HUMAN antibody; DANTE antibody; GREM3 antibody; Gremlin-3 antibody; MGC126849 antibody; SP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human DAN domain family member 5 protein (23-189AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，DAND5 Antibody (CSB-PA850835LA01HU)，的标记方式是Non-conjugated。对于DAND5 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA850835LB01HU DAND5 Antibody, HRP conjugated ELISA
    FITC CSB-PA850835LC01HU DAND5 Antibody, FITC conjugated
    Biotin CSB-PA850835LD01HU DAND5 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation.
  • 基因功能参考文献：
    1. High DAND5 expression is associated with tumor growth and angiogenesis in breast cancer. PMID: 26908452
    2. In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G > A) in the functional domain of the DAND5 protein (p.R152H), a master regulator of Nodal signaling. Patient 1 presents left isomerism, ventricular septal defect with overriding aorta and pulmonary atresia, while patient 2 presents ventricular septal defect with overriding aorta, right ventricular hypertrophy PMID: 28738792
    3. A gain-of-function cDNA screen reveals that Coco, a secreted antagonist of TGF-beta ligands, induces dormant breast cancer cells to undergo reactivation in the lung. PMID: 22901808
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 数据库链接：

    HGNC: 26780

    OMIM: 609068

    KEGG: hsa:199699

    STRING: 9606.ENSP00000323155

    UniGene: Hs.331981