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Ctsk Antibody

  • 货号：
    CSB-PA006192LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA006192LA01RA at dilution of 1:20
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Ctsk Polyclonal antibody
  • Uniprot No.：
    O35186
  • 基因名：
  • 别名：
    Ctsk antibody; Cathepsin K antibody; EC 3.4.22.38 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat
  • 免疫原：
    Recombinant Rat Cathepsin K protein (115-329AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Ctsk Antibody (CSB-PA006192LA01RA)，的标记方式是Non-conjugated。对于Ctsk Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006192LB01RA Ctsk Antibody, HRP conjugated ELISA
    FITC CSB-PA006192LC01RA Ctsk Antibody, FITC conjugated
    Biotin CSB-PA006192LD01RA Ctsk Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:10-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen.
  • 基因功能参考文献：
    1. the present study identified icariin as a novel therapeutic agent in DXM-induced cartilage injury in rats, and revealed that the activation of miR-206 targeting of cathepsin K may be responsible for the chondroprotective efficacy of icariin PMID: 29207029
    2. cathepsin K, in both its secreted and lysosomal forms, may play a role in the degradation of Sertoli cell residual bodies PMID: 14585819
    3. In conclusion, according to its ability to modulate hypotensive effects of kinins, we propose that cathepsin K is a kininase of biological relevance. PMID: 17181996
    4. Comparison of the S2 site between rat and human cathepsin K sequences indicated that two S2 residues at Ser134 and Val160 in rat are varied to Ala and Leu, respectively, in the human enzyme. PMID: 18664521
    5. The expression pattern of Ctsk in osteoclasts in physiological root resorption in the rat molar was determined. PMID: 18974601

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  • 亚细胞定位：
    Lysosome. Secreted. Apical cell membrane; Peripheral membrane protein; Extracellular side.
  • 蛋白家族：
    Peptidase C1 family
  • 数据库链接：

    KEGG: rno:29175

    STRING: 10116.ENSRNOP00000028730

    UniGene: Rn.5598