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Cleaved-ITGA7 (E959) Antibody

  • 货号：
    CSB-PA000073
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using Cleaved-Integrin α7 LC (E959) Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q13683
  • 基因名：
  • 别名：
    alpha 7 antibody; FLJ25220 antibody; Integrin alpha 7 antibody; Integrin alpha 7 chain antibody; Integrin alpha 7 heavy chain antibody; Integrin alpha 7 light chain antibody; Integrin alpha-7 70 kDa form antibody; ITA7_HUMAN antibody; ITGA 7 antibody; Itga7 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Monkey
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Integrin α7 LC.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
  • 基因功能参考文献：
    1. Speculate that the postnatal splicing of alpha7A to alpha7B and of beta1A to beta1D integrins is delayed, altering spontaneous descent of the testes in the first months of life. PMID: 30089289
    2. As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. PMID: 27924820
    3. targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. PMID: 28602620
    4. Taken together, these results further support the use of a7 integrin as a potential therapy for Duchenne muscular dystrophy PMID: 26076707
    5. Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. PMID: 26320193
    6. Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. PMID: 26011651
    7. ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells. PMID: 23830872
    8. The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. PMID: 24227711
    9. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7] PMID: 23800289
    10. Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury. PMID: 24091324
    11. This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. PMID: 20651226
    12. ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression. PMID: 20460506
    13. conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology PMID: 12057917
    14. FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells PMID: 15117962
    15. alpha7-expressing fetal myoblasts are capable of differentiation to osteoblast lineage with a coordinated switch in integrin profiles and may represent a mechanism that promotes homing and recruitment of myogenic stem cells for tissue remodeling. PMID: 17054947
    16. Integrin alpha7 mutations are associated with prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma PMID: 17551147
    17. analysis of how distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms PMID: 17618648
    18. Alpha7B is a novel marker of the contractile phenotype, and alpha7 expression is essential for human airway smooth muscle cell maturation, which is a laminin-dependent process. PMID: 17641293
    19. cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions. PMID: 18940796
    20. laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts PMID: 19416897

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  • 相关疾病：
    Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)
  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Integrin alpha chain family
  • 组织特异性：
    Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes
  • 数据库链接：

    HGNC: 6143

    OMIM: 600536

    KEGG: hsa:3679

    STRING: 9606.ENSP00000452120

    UniGene: Hs.524484