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Cd74 Antibody

  • 货号：
    CSB-PA004956LA01RA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Cd74 antibody at 2µg/ml + Mouse lung tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 32, 25 kDa
      Observed band size: 32 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Rattus norvegicus (Rat) Cd74 Polyclonal antibody
  • Uniprot No.：
    P10247
  • 基因名：
  • 别名：
    Cd74 antibody; H-2 class II histocompatibility antigen gamma chain antibody; Ia antigen-associated invariant chain antibody; Ii antibody; MHC class II-associated invariant chain antibody; CD antigen CD74) [Cleaved into: Class-II-associated invariant chain peptide antibody; CLIP)] antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Rat, Mouse
  • 免疫原：
    Recombinant Rat H-2 class II histocompatibility antigen gamma chain protein (57-280AA)
  • 免疫原种属：
    Rattus norvegicus (Rat)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Cd74 Antibody (CSB-PA004956LA01RA)，的标记方式是Non-conjugated。对于Cd74 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004956LB01RA Cd74 Antibody, HRP conjugated ELISA
    FITC CSB-PA004956LC01RA Cd74 Antibody, FITC conjugated
    Biotin CSB-PA004956LD01RA Cd74 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44.; Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.; Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs).
  • 基因功能参考文献：
    1. cytokine MIF was able to elicit inflammatory response of astrocytes through interaction with CD74 receptor, and activation of ERK was necessary for the intracellular signal transduction. PMID: 27926507
    2. Methylglyoxal induced gene expression of CD74 in the in the diabetic retina. PMID: 24974304
    3. Macrophage migration inhibitory factor(MIF)/CD74 interaction induces upregulation of cyclooxygenase (COX)-2 and prostaglandin E2 secretion in primary rodent microglia. PMID: 21802455
    4. Data indicate that intraluminal macrophage migration inhibitory factor, released from urothelial cells as a consequence of substance P treatment, interacts with urothelial cell-surface CD74. PMID: 19325914
    5. Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat PMID: 19503733

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  • 亚细胞定位：
    [Isoform Long]: Late endosome. Lysosome.; Cell membrane; Single-pass type II membrane protein. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome.
  • 数据库链接：

    KEGG: rno:25599

    STRING: 10116.ENSRNOP00000025354

    UniGene: Rn.33804