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Cd46 Antibody

  • 货号：
    CSB-PA004939LA01MO
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse skeletal muscle tissue
      All lanes: Cd46 antibody at 4µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 34 kDa
      Observed band size: 41 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA004939LA01MO at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Mus musculus (Mouse) Cd46 Polyclonal antibody
  • Uniprot No.：
    O88174
  • 基因名：
  • 别名：
    Cd46 antibody; McpMembrane cofactor protein antibody; CD antigen CD46 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse
  • 免疫原：
    Recombinant Mouse Membrane cofactor protein (45-329AA)
  • 免疫原种属：
    Mus musculus (Mouse)
  • 标记方式：
    Non-conjugated

    本页面中的产品，Cd46 Antibody (CSB-PA004939LA01MO)，的标记方式是Non-conjugated。对于Cd46 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004939LB01MO Cd46 Antibody, HRP conjugated ELISA
    FITC CSB-PA004939LC01MO Cd46 Antibody, FITC conjugated
    Biotin CSB-PA004939LD01MO Cd46 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be involved in the fusion of the spermatozoa with the oocyte during fertilization.
  • 基因功能参考文献：
    1. Changes in CD46 expression may lead to changes in VEGF and play a pathologic role in the development of age-related macular degeneration. PMID: 26161984
    2. Our findings provide evidence for expression of CD46 in the mouse eye and a role for CD46 in protection against laser-induced choroidal neovascularization PMID: 25019227
    3. This fusion is mediated by the interaction between viral glycoproteins expressed on the membrane of the infected cells and CD46 on the glial targets, and is also observed using cells expressing recombinant MV glycoproteins. PMID: 15920733
    4. CD46 isoforms function as receptors for human herpesvirus 6 and measles virus PMID: 12171934
    5. Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm and increased male fertility PMID: 12640142
    6. CD46 has a role as a receptor for fusion and entry of human herpesvirus 6 into target cells PMID: 12724329

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  • 亚细胞定位：
    [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane; Single-pass type I membrane protein. Note=Inner acrosomal membrane of spermatozoa.; [Isoform 2]: Secreted.
  • 组织特异性：
    Present only in testis (at protein level).
  • 数据库链接：

    KEGG: mmu:17221

    STRING: 10090.ENSMUSP00000123931

    UniGene: Mm.12884