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CYREN Antibody

  • 货号：
    CSB-PA883613HA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA883613HA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CYREN Polyclonal antibody
  • Uniprot No.：
    Q9BWK5
  • 基因名：
    CYREN
  • 别名：
    C7orf49 antibody; Chromosome 7 open reading frame 49 antibody; Modulator of retrovirus infection homolog antibody; MRI antibody; MRI_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cell cycle regulator of non-homologous end joining protein (1-157AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CYREN Antibody (CSB-PA883613HA01HU)，的标记方式是Non-conjugated。对于CYREN Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA883613HB01HU CYREN Antibody, HRP conjugated ELISA
    FITC CSB-PA883613HC01HU CYREN Antibody, FITC conjugated
    Biotin CSB-PA883613HD01HU CYREN Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase. Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70. In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination. May also act as an indirect regulator of proteasome.
  • 基因功能参考文献：
    1. proposition that CYREN is a direct cell-cycle-dependent inhibitor of cNHEJ that promotes error-free repair by homologous recombination during cell cycle phases when sister chromatids are present PMID: 28959974
    2. Interacts with Ku and enhances efficiency of DNA double strand break ligation in vitro PMID: 24610814
    3. Characterizes the hamster ortholog and suggests that it may modulate the ability of the proteasome to degrade retroviral cores upon cellular infection. PMID: 17043244
  • 亚细胞定位：
    [Isoform 1]: Cytoplasm. Nucleus. Chromosome.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm. Nucleus.
  • 数据库链接：

    HGNC: 22432

    OMIM: 616980

    KEGG: hsa:78996

    STRING: 9606.ENSP00000376823

    UniGene: Hs.643113