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CYP4Z1 Antibody

  • 货号：
    CSB-PA008006
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q86W10
  • 基因名：
    CYP4Z1
  • 别名：
    CYP4Z1 antibody; UNQ3060/PRO9882Cytochrome P450 4Z1 antibody; EC 1.14.14.1 antibody; CYPIVZ1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CYP4Z1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase that catalyzes the in-chain oxidation of fatty acids. Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates lauric and myristic acids predominantly at the omega-4 and omega-2 positions, respectively. Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Displays an absolute stereoselectivity in the epoxidation of arachidonic acid producing the 14(S),15(R)-epoxyeicosatrienoic acid (EET) enantiomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
  • 基因功能参考文献：
    1. If CYP4Z1 has a role to play in modulating cancer progression, new data form yeast microsomes expressing recombinant human enzyme suggest that the mechanism does not involve direct 20-HETE generation by this enzyme. PMID: 29018033
    2. This study reports on the creation of a new homology model of CYP4Z1 and performed molecular docking experiments, which indicate that all active substrates show a highly similar binding geometry compared to the endogenous substrates. PMID: 28951277
    3. CYP4Z1 3'UTR could inhibit the migration and Epithelial-mesenchymal transition of breast cancer cells. PMID: 27520371
    4. CYP4Z1 and CYP4Z2P were downregulated in MCF-7 cells compared with tamoxifen-resistant MCF-7-TamR cells PMID: 26980484
    5. CYP4Z1 overexpression promotes tumor angiogenesis and growth in breast cancer partly via PI3K/Akt and ERK1/2 activation PMID: 22841774
    6. Human cytochrome P450 (CYP), termed CYP4Z1,was identified, and the cDNA was cloned from a breast carcinoma line . PMID: 15059886
    7. PPARalpha has a role in CYP4X1 regulation, and the glucocorticoid and progesterone receptors have roles in CYP4Z1 gene activation PMID: 15797250
    8. CYP4Z1-dependent in-chain hydroxylation of lauric and myristic acid, which in both cases leads to the formation of four different monohydroxylated products at positions omega-2, omega-3, omega-4, and omega-5, respectively PMID: 19090726

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Preferentially detected in breast carcinoma tissue and mammary gland, whereas only marginal expression is found in all other tested tissues.
  • 数据库链接：

    HGNC: 20583

    KEGG: hsa:199974

    STRING: 9606.ENSP00000334246

    UniGene: Hs.176588