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CYP2A13 Antibody

  • 货号：
    CSB-PA621969LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Mouse liver tissue
      All lanes: CYP2A13 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • IHC image of CSB-PA621969LA01HU diluted at 1:200 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CYP2A13 Polyclonal antibody
  • Uniprot No.：
    Q16696
  • 基因名：
    CYP2A13
  • 别名：
    Cytochrome P450 2A13 (EC 1.14.14.1) (CYPIIA13), CYP2A13
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human Cytochrome P450 2A13 protein (252-354aa)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CYP2A13 Antibody (CSB-PA621969LA01HU)，的标记方式是Non-conjugated。对于CYP2A13 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA621969LB01HU CYP2A13 Antibody, HRP conjugated ELISA
    FITC CSB-PA621969LC01HU CYP2A13 Antibody, FITC conjugated
    Biotin CSB-PA621969LD01HU CYP2A13 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.
  • 基因功能参考文献：
    1. CYP2A13 is the most efficient enzyme to metabolize N'-Nitrosonornicotine in vitro. PMID: 27567546
    2. The results of this case-control study suggested that the CYP2A13*1/*2 genotype decreased the risk of susceptibility to bladder cancer in Japanese smokers PMID: 27725446
    3. CYP2A13 levels in human lungs can be suppressed by disease-associated inflammation in tissue donors. PMID: 25710941
    4. an etiologically relevant interaction between CYP2A13 and ABCB1 associated with lung cancer was analysed PMID: 25667220
    5. The transgenic CYP2A13 is active. PMID: 24907355
    6. CYP2A13 played a critical role in AFB1-induced neoplastic transformation. PMID: 24114584
    7. Data suggest important role of CYP2A13 in AFG1- (aflatoxin G1)-induced cytotoxicity, DNA damage, and activation of signal pathways in bronchial epithelium; data suggest similarities in CYP2A13-catalyzed bioactivation of AFG1 and AFB1 (aflatoxin B1). PMID: 23907605
    8. CYP2A13 is efficient in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone bioactivation in vivo and it can mediate 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis. PMID: 23917075
    9. Findings suggest the potential involvement of pulmonary CYP2A13 in the early occurrence of NSCLC as well as in the development of EGFR gene mutations. PMID: 23752126
    10. an efficient approach for expressing functionally characterized, highly active and homogeneous CYP2A13 proteins. PMID: 23463547
    11. CYP2A13 plays an important role in low-concentration AFB1-induced DNA damage, possibly linking environmental airborne AFB1 to genetic injury in the human respiratory system. PMID: 23583631
    12. Findings suggest that CYP2A13 plays an important role in low-concentration AFB1-induced DNA damage, possibly linking environmental airborne AFB1 to genetic injury in human respiratory system. PMID: 23602888
    13. The differential distribution pattern of CYP2A13 in the respiratory tract, which is of importance in considering the pulmonary susceptibility to carcinogens and the following lung cancer development, is detailed. PMID: 22890016
    14. Tissue distribution of transgenic mRNA expression agrees well with the known respiratory tract-selective expression of CYP2A13 and CYP2F1 and hepatic expression of CYP2B6 in humans. PMID: 22397853
    15. Report selective expression of CYP2A13 in human pancreatic alpha-islet cells. PMID: 22798551
    16. Although both the hepatic CYP2A6 and respiratory CYP2A13 enzymes metabolize these compounds, CYP2A13 does so with much higher catalytic efficiency, but the structural basis for this has been unclear PMID: 22700965
    17. The distribution frequencies of all eight known CYP2A13 missense alleles were examined in a Chinese Han population. PMID: 22315333
    18. present results provide the first direct in vitro evidence demonstrating the predominant roles of CYP2A13 in 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced mutagenesis, possibly via metabolic activation of NNK alpha-hydroxylation PMID: 21473878
    19. single nucleotide polymorphisms within the CYP2A13 gene affect metabolism of 5-methoxypsoralen in humans. PMID: 20798279
    20. 2 novel polymorphisms T478C and T494C in CYP2A13 gene were associated with significantly reduced risk of cancer. CYP2A13 haplotype carrying variant alleles of T478C/T494C found associated with reduced risk of head/neck cancer. PMID: 20534012
    21. significant interaction between smoking and methylation status of CYP2A13 in head and neck cancer. PMID: 20846153
    22. The mechanisms underlying the decreased allelic expression of a common CYP2A13 allele (7520C>G) in the human lung, were investigated. PMID: 20431511
    23. Observed clear prevalence of the variant CYP2A13 alelle causing premature stop at codon 101 (knockout allele *7) among the controls in comparison with the pancreatic cancer patients. PMID: 19812523
    24. genetic polymorphism: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant PMID: 12130698
    25. CYP2A13 allele is associated with reduced risk of lung adenocarcinoma, suggesting the role of NNK-CYP2A13 interaction as a causative factor for the cancer. PMID: 14633739
    26. In order to investigate the extent of CYP2A13 genetic polymorphism in a French Caucasian population of 102 individuals, a screening for sequence variations in the 5'-untranslated and protein encoding regions of its gene was performed. PMID: 15063809
    27. The CYP2A13 Arg257Cys variant represents a common polymorphism in Chinese, with the 257Cys allele frequency being similar to the Hispanic and Asian groups, but significantly lower than in blacks PMID: 15115698
    28. CYP2A13 mutant proteins showed a significant decrease in the catalytic efficiency for NNK alpha-hydroxylation PMID: 15333516
    29. structure of CYP2A13 was determined to 2.35A by x-ray crystallography and compared with structures of CYP2A6. PMID: 17428784
    30. the reported association of the CYP2A13(*)2 allele with decreased incidences of lung adenocarcinoma in smokers can be at least partly explained by a decrease in CYP2A13 function PMID: 18669584

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.
  • 数据库链接：

    HGNC: 2608

    OMIM: 608055

    KEGG: hsa:1553

    STRING: 9606.ENSP00000332679

    UniGene: Hs.567252