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CYFIP1 Antibody

  • 货号：
    CSB-PA748722LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of A549 cells with CSB-PA748722LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CYFIP1 Polyclonal antibody
  • Uniprot No.：
    Q7L576
  • 基因名：
  • 别名：
    CY antibody; CYFIP 1 antibody; CYFIP1 antibody; CYFP1_HUMAN antibody; Cytoplasmic FMR1 interacting protein 1 antibody; Cytoplasmic FMR1-interacting protein 1 antibody; FLJ45151 antibody; KIAA0068 antibody; p140sra 1 antibody; p140sra-1 antibody; P140SRA1 antibody; Selective hybridizing clone antibody; SHYC antibody; Specifically Rac1 associated protein 1 antibody; Specifically Rac1-associated protein 1 antibody; SRA 1 antibody; Sra-1 antibody; SRA1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytoplasmic FMR1-interacting protein 1 protein (320-449AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CYFIP1 Antibody (CSB-PA748722LA01HU)，的标记方式是Non-conjugated。对于CYFIP1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA748722LB01HU CYFIP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA748722LC01HU CYFIP1 Antibody, FITC conjugated
    Biotin CSB-PA748722LD01HU CYFIP1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA. Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes. May act as an invasion suppressor in cancers.
  • 基因功能参考文献：
    1. CYFIP1 gene expression was upregulated in the blood of epileptic patients. PMID: 29992499
    2. The studies suggest that MNK-eiF4E axis controls the translation of specific mRNAs in cancer metastasis and neuronal synaptic plasticity by a novel mechanism involving the regulation of the translational repressor, CYFIP1. (Review) PMID: 27527252
    3. rs4778298, a common variant at CYFIP1 is associated with inter-individual variation in surface area across the left supramarginal gyrus. PMID: 27351196
    4. Both mRNA and protein expression levels of Cyfip1 were significantly lower in ALL patients. PMID: 26779626
    5. Reduced CYFIP1 in human neural progenitors results in dysregulation of schizophrenia and epilepsy gene networks. PMID: 26824476
    6. Hippocampal synapses with reduced Cyfip1 are larger and release neurotransmitter more rapidly. PMID: 26843638
    7. Data confirm that CYFIP1 is upregulated in transformed lymphoblastoid cell lines and demonstrate its upregulation in the post-mortem brain from 15q11-13 duplication patients for the first time PMID: 25311365
    8. This study confirmed that CYFIP2 were altered in postsynaptic density in patient with schizophrenia. PMID: 25048004
    9. haploinsufficiency causes cell polarity defects via WAVE complex destabilization; genetic polymorphism is associated with schizophrenia PMID: 24996170
    10. An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. PMID: 24442360
    11. Protein complexes containing CYFIP/Sra/PIR121 coordinate Arf1 and Rac1 signalling during clathrin-AP-1-coated carrier biogenesis at the trans-golgi network. PMID: 20228810
    12. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes PMID: 14508708
    13. CRMP-2 transports the Sra-1/WAVE1 complex to axons in a kinesin-1-dependent manner and thereby regulates axon outgrowth and formation PMID: 16260607
    14. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales PMID: 16982806
    15. Study found that Cyfip1, a subunit of the WAVE complex, which regulates cytoskeletal dynamics, is commonly deleted in human epithelial cancers. PMID: 19524508

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  • 亚细胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell projection, lamellipodium. Cell projection, ruffle. Cell junction, synapse, synaptosome.
  • 蛋白家族：
    CYFIP family
  • 数据库链接：

    HGNC: 13759

    OMIM: 606322

    KEGG: hsa:23191

    STRING: 9606.ENSP00000324549

    UniGene: Hs.26704