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CYBRD1 Antibody

  • 货号：
    CSB-PA006326LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of Hela cells with CSB-PA006326LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CYBRD1 Polyclonal antibody
  • Uniprot No.：
    Q53TN4
  • 基因名：
    CYBRD1
  • 别名：
    CYBRD1; DCYTB; FRRS3; Plasma membrane ascorbate-dependent reductase CYBRD1; Cytochrome b reductase 1; Duodenal cytochrome b; Ferric-chelate reductase 3
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cytochrome b reductase 1 protein (220-286AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CYBRD1 Antibody (CSB-PA006326LA01HU)，的标记方式是Non-conjugated。对于CYBRD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA006326LB01HU CYBRD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA006326LC01HU CYBRD1 Antibody, FITC conjugated
    Biotin CSB-PA006326LD01HU CYBRD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes. It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood. May also act as a ferrireductase in airway epithelial cells. May also function as a cupric transmembrane reductase.
  • 基因功能参考文献：
    1. Single nucleotide polymorphism in CYBRD1 gene is associated with hemochromatosis. PMID: 28937159
    2. CYBRD1 has an involvement in iron homeostasis in chronic hepatitis C. PMID: 27439017
    3. DCYTB is an important predictor of outcome and is associated with response to therapy in breast cancer patients. PMID: 28270217
    4. Polymorphisms in CYBRD1 modulates iron phenotype in HFE p.C282Y homozygous hemochromatosis. PMID: 22773607
    5. Letter: report mutations in CYBRD1 promoter in and possible role in iron hemostasis in patients with porphyria cutanea tarda. PMID: 23012398
    6. In Africans with iron overload not related to the HFE gene, the possible involvement of the SLC40A1 and CYBRD1 genes was demonstrated for the first time. PMID: 15338274
    7. Duodenal cytochrome b present in human erythrocytes may contribute to their ability to reduce extracellular monodehydroascorbate. PMID: 17068337
    8. The current study concerns the recombinant expression, purification, and initial spectroscopic characterization of a recombinant form of the human ferric reductase. PMID: 18092813
    9. Functional characterization of Cybrd1 heme groups and iron/ascorbate metabolism. PMID: 18194661
    10. The results of this study confirm that Dcytb can act as a ferric reductase that stimulates iron uptake in Caco-2 cells. PMID: 18492824

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein.
  • 组织特异性：
    Present in erythrocyte membranes (at protein level). Also expressed in respiratory epithelium.
  • 数据库链接：

    HGNC: 20797

    OMIM: 605745

    KEGG: hsa:79901

    STRING: 9606.ENSP00000319141

    UniGene: Hs.221941