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CYB5R4 Antibody

  • 货号：
    CSB-PA006321GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q7L1T6
  • 基因名：
    CYB5R4
  • 别名：
    b5+b5R antibody; b5b5r antibody; C79736 antibody; cb5/cb5R antibody; Cb5cb5r antibody; Cyb5r4 antibody; Cytochrome b type NAD(P)H oxidoreductase antibody; Cytochrome b5 reductase 4 antibody; dJ676J13.1 antibody; Flavohemoprotein b5+b5R antibody; Flavohemoprotein b5/b5R antibody; N terminal cytochrome b5 and cytochrome b5 oxidoreductase domain containing protein antibody; N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein antibody; NADPH cytochrome B5 oxidoreductase antibody; NB5R4_HUMAN antibody; NCB5OR antibody; RP4 676J13.1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CYB5R4
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.
  • 基因功能参考文献：
    1. Cytosolic localization of NADH cytochrome b oxidoreductase PMID: 26878259
    2. data provide first evidence for natural mutations in NCB5OR gene resulting in decreased protein levels and hence having potential implications in human pathology. PMID: 23523930
    3. Mutation in cytochrome b5 reductase is associated with developmental delay and severe neurological problems. PMID: 22627575
    4. Study of the individual cytochrome b5 and cytochrome b5 reductase domains of Ncb5or reveals a unique heme pocket and a possible role of the CS domain. PMID: 20630863
    5. NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum PMID: 15131110
    6. Variaation in the coding region is not a major contributor in the pathogenesis of nonautoimmune diabetes. PMID: 15504981

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  • 亚细胞定位：
    Endoplasmic reticulum. Note=Soluble protein.
  • 蛋白家族：
    Flavoprotein pyridine nucleotide cytochrome reductase family
  • 组织特异性：
    Widely expressed.
  • 数据库链接：

    HGNC: 20147

    OMIM: 608343

    KEGG: hsa:51167

    STRING: 9606.ENSP00000358695

    UniGene: Hs.5741