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CXXC1 Antibody

  • 货号：
    CSB-PA006300GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9P0U4
  • 基因名：
    CXXC1
  • 别名：
    2410002I16Rik antibody; 5830420C16Rik antibody; AI426635 antibody; CFP 1 antibody; CFP1 antibody; CpG binding protein antibody; CpG-binding protein antibody; CXXC 1 antibody; CXXC finger 1 antibody; CXXC finger 1 PHD domain antibody; CXXC finger protein 1 antibody; CXXC type zinc finger protein 1 antibody; CXXC-type zinc finger protein 1 antibody; CXXC1 antibody; CXXC1_HUMAN antibody; DNA binding protein with PHD finger and CXXC domain antibody; hCGBP antibody; HsT2645 antibody; PCCX 1 antibody; PCCX1 antibody; PHD finger and CXXC domain containing protein 1 antibody; PHD finger and CXXC domain-containing protein 1 antibody; PHF 18 antibody; PHF18 antibody; Protein containing CXXC domain 1 antibody; SPP 1 antibody; SPP1 antibody; ZCGPC 1 antibody; ZCGPC1 antibody; Zinc finger; CpG binding type containing 1 antibody
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CXXC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20oC, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that exhibits a unique DNA binding specificity for CpG unmethylated motifs with a preference for CpGG.
  • 基因功能参考文献：
    1. CFP1 binds open chromatin regions of active genes, including enhancers and non-CpG islands. PMID: 30292235
    2. directly controls the expression of key genes important for thymocyte survival, such as RORgammat, and for T-cell receptor signaling, including Zap70 and CD8, through maintaining the appropriate H3K4me3 on their promoters PMID: 27210293
    3. NF-kappaB recruitment enhanced the occupancy of the CpG island within the 14-3-3gamma promoter by CFP1.14-3-3gamma induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-kappaB and sustained by E2A. PMID: 23851690
    4. The crescent-shaped CFP1 CXXC domain is wedged into the major groove of the CpG DNA, distorting the B-form DNA, and interacts extensively with the major groove of the DNA. PMID: 21407193
    5. CXXC finger protein 1 is a component of the mammalian Set1 histone H3-Lys4 methyltransferase complex PMID: 16253997
    6. CXXC finger protein 1 is required for normal proliferation and differentiation of the PLB-985 myeloid cell line. PMID: 17328666
    7. CGBP interacts with MLL1, MLL2 as well as Set1 H3-Lysine 4 (H3K4) specific methyl-transferases and plays critical roles in regulations of MLL target genes. PMID: 18082152
    8. study shows endogenous DNMT1 & CFP1 interact in vivo; CFP1 interaction with Setd1A or Setd1B not required for its interaction with DNMT1; result indicates CFP1 intersects cytosine methylation machinery independently of its association with Setd1 complexes PMID: 18680430
    9. expression of either the amino half of Cfp1 (amino acids 1 to 367 [Cfp1(1-367)]) or the carboxyl half of Cfp1 (Cfp1(361-656)) is sufficient to correct all of the defects observed with embryonic stem cells that lack Cfp1 PMID: 19433449

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  • 亚细胞定位：
    Nucleus speckle. Nucleus. Note=Associated with euchromatin. During mitosis, excluded from condensed chromosomes.
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 24343

    OMIM: 609150

    KEGG: hsa:30827

    STRING: 9606.ENSP00000390475

    UniGene: Hs.180933