CTSG Antibody

1. CTSG was increased in peripheral blood mononuclear cells and muscle tissues of dermatomyositis (DM) patients, and CTSG activity was higher in the serum of DM patients PMID: 28797985
2. CatG can be used as a novel marker to distinguish different NK cell subsets and MARS116 is applicable to determine cell surface CatG activity by flow cytometry. PMID: 27666013
3. Results provide evidence that cathepsin G (GC) activates IGF-1R by stimulating IGF-1 release from MCF-7 cells, and that IGF-1R activation is required for CG-induced cell aggregation. PMID: 28544544
4. Cleavage of the alarmins by Human mast cell chymase and human neutrophil cathepsin G suggests a function in regulating excessive inflammation. PMID: 28053237
5. Data show that lactoferrin (LF) increases the catalytic activity of cathepsin G (CatG) at physiological concentration. PMID: 26986619
6. CatG is an essential protease for regulating MHC I molecules PMID: 26837514
7. Patients with certain polymorphisms in the CTSG gene had lower risk for chronic postsurgical pain compared with wild-types. PMID: 26270939
8. These in vivo data provide, for the first time, compelling evidence of the collateral involvement of cathepsin G, NE, and proteinase 3 in cigarette smoke-induced tissue damage and emphysema PMID: 24929239
9. expression levels of ELANE and CTSG were determined by quantitative real-time PCR PMID: 25248056
10. Elastase and cathepsin G are elevated in the plasma of HD patients, originating from primed PMNLs. In these patients, chronic elevation of these enzymes contributes to cleavage of VE-cadherin and possible disruption of endothelial integrity. PMID: 24877096
11. Cathepsin G is an antimicrobial protein with bacteriocidal activity against S. aureus and N. gonorrhoeae. PMID: 2116408
12. proteolytic cleavage of PLTP by cathepsin G may enhance the injurious inflammatory responses that occur in COPD PMID: 24532668
13. Neutrophil cathepsin G is a physiologic modulator of platelet thrombus formation in vivo and has potential as a target for novel anti-thrombotic therapies. PMID: 23940756
14. demonstrate that cathepsin G (CG), neutrophil elastase (NE), and to a lesser extent proteinase 3 (PR3), degrade endocan PMID: 23454598
15. A novel HLA-A*0201 restricted peptide derived from cathepsin G is an effective immunotherapeutic target in acute myeloid leukemia. PMID: 23147993
16. the targeting and suppression of CTSG by AML1-ETO in t(8;21) AML may provide a mechanism for leukemia cells to escape from the intracellular surveillance system by preventing degradation of foreign proteins. PMID: 22641217
17. NE and CG bind to the surface of cancer cells, presumably to a cell surface receptor, and subsequently undergo clathrin pit-mediated endocytosis. PMID: 22915586
18. major binding partners of LEKTI were found to be the antimicrobial peptide dermcidin and the serine protease cathepsin G and no kallikreins. PMID: 22588119
19. Data suggested the notion that CatG plays a critical role in proinsulin processing and is important in the activation process of diabetogenic T cells. PMID: 21850236
20. potential of HNE and CatG to be used as markers for early detection of infection. Significant differences in HNE and CatG levels in infected and non-infected wound fluids were observed. PMID: 21488974
21. CatG was found to be dispensable in invariant chain conversion within intact primary human B cells and dendritic cells. PMID: 21543057
22. distinct catK/C4-S interactions are necessary for the collagenolytic activity of the enzyme. PMID: 21193413
23. Neutrophil cathepsin G can either facilitate or impede coagulation via effects on thrombin generation. PMID: 20589323
24. CatG cleaves human leukocyte antigen (HLA)-DR in vitro. Cleavage occurred on the loop between fx1 and fx2 of the membrane-proximal beta2 domain. In vivo, however, the CatG cleavage site is sterically inaccessible or masked by associated molecules. PMID: 20331476
25. Historical and recent data on CatG expression, distribution, function and involvement in disease will be summarized and discussed, with a focus on its role in antigen presentation and immune-related events. PMID: 19910052
26. high molecular mass kininogen down-regulates cathepsin G-induced platelet activation by forming a complex with cathepsin G and thus prevents binding of cathepsin G to platelets PMID: 11920276
27. UVA light stimulates the production of cathepsin G and elastase-like enzymes by dermal fibroblasts: a possible contribution to the remodeling of elastotic areas in sun-damaged skin. PMID: 11928814
28. up-regulated by the AML1-MTG8 fusion protein, suggesting a role in the granulocytic maturation characteristic of the t(8;21) acute myelogenous leukemia PMID: 11986950
29. cathepsin G enhances fibrin deposition under flow conditions by elevating the activation state of fibrinogen-adherent platelets rather than by cleaving coagulation factors PMID: 12524437
30. BPI and cathepsin G are the major antigenic targets of ANCA seen in patients with systemic sclerosis PMID: 12784398
31. Serine proteinases cathepsin G and neutrophil elastase cooperate for the proteolytic regulation of CD87/urokinase receptor on monocytic cells. PMID: 14688365
32. role in development of myelodi leukemia with promyelocytic features PMID: 14737102
33. Cathepsin G initializes and dominates the destruction of intact myelin basic protein (MBP) by B cell-derived lysosomal extracts, degrading immunodominant MBP epitope and eliminating both its binding to HLA-DRB1*1501 and MBP-specific T cell response. PMID: 15100291
34. neutrophil elastase and cathepsin G are inhibited by PAI-1 mutants PMID: 15131125
35. Release of cathepsin G from neutrophils specifically down-regulates the responsiveness of neutrophils to C5a, and this effect may play a role in the down-regulation of acute inflammation. PMID: 15140022
36. down-regulation of CatG in macrophages is advantageous to M. tuberculosis bacilli and possibly is an important mechanism by which M. tuberculosis is able to evade the host immune defenses PMID: 15385470
37. oxidants generated by myeloperoxidase regulate cathepsin G activity in vivo PMID: 15967795
38. Neutrophil cathepsin G is the principal protease to produce CCL15 proteolytic products released in the course of hemofiltration of blood from renal insufficiency patients PMID: 16034099
39. PF-4 acts as an inhibitor of the CTAP-III-processing enzymes cathepsin G and chymase without becoming cleaved itself as a competitive substrate. PMID: 16317101
40. the monocyte chemotactic activity of cathepsin G may have a role in the pathogenesis of RA synovial inflammation PMID: 16977463
41. cathepsin g may play a role in the progression to heart failure by activating angiotensin II, leading to detrimental effects on the heart PMID: 17418861
42. Substrate specificity for cathepsin G is greatly enhanced when an aromatic side chain and a strong positive charge are incorporated in residue P(1). PMID: 17653609
43. Cathepsin G from neutrophils and monocytes may provide some pro-coagulant effect by activating FVIII. PMID: 18217133
44. The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramembrane proteolysis by presenilin/gamma-secretase PMID: 18586676
45. Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1. PMID: 18835135
46. Data report that the two subsets of human dendritic cells differ in their cathepsin distribution, and suggest tha Cathepsin G may be of functional importance. PMID: 19036358
47. MC are immunoreactive to cathepsin-G in human cutaneous mastocytosis, as well as the co-localization of tryptase and cathepsin-G in MC secretory granules. PMID: 19250736
48. both Cat-G and PAR(4) play key roles in generating and/or amplifying relapses in ulcerative colitis PMID: 19528350
49. Cathepsin G is one of the mediators responsible for complement-dependent opsonophagocytic killing of Streptococcus pneumoniae by human neutrophils. PMID: 19620298

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HGNC: 2532

OMIM: 116830

KEGG: hsa:1511

STRING: 9606.ENSP00000216336

UniGene: Hs.421724