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CTDSP1 Antibody

  • 货号：
    CSB-PA001818
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using CTDSP1 Polyclonal Antibody
    • Western blot analysis of mouse-brain HELA KB SH-SY5Y 293T 3T3 lysis using CTDSP1 antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q9GZU7
  • 基因名：
    CTDSP1
  • 别名：
    Carboxy terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 antibody; CTD (carboxy terminal domain RNA polymerase II polypeptide A) small phosphatase 1 antibody; CTD small phosphatase 1 antibody; CTDS1_HUMAN antibody; CTDSP1 antibody; NIF3 antibody; NLI IF antibody; NLI interacting factor 3 antibody; NLI-IF antibody; NLI-interacting factor 3 antibody; NLIIF antibody; Nuclear LIM interactor interacting factor 3 antibody; Nuclear LIM interactor-interacting factor 3 antibody; SCP1 antibody; Small C-terminal domain phosphatase 1 antibody; Small CTD phosphatase 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human CTDSP1.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells.
  • 基因功能参考文献：
    1. SCP1 is the phosphatase that counterregulates the MAPK-mediated phosphorylation of Ser(68)-Twist1. PMID: 26975371
    2. SCP1 regulates c-Myc stability and functions through dephosphorylating c-Myc Serine-62. PMID: 25893300
    3. hSCP1 may be an beta-O-linked N-acetylglucosamine modified protein in vivo. PMID: 25081999
    4. CTDSP1 activity stabilizes REST in stem cells and ERK-dependent phosphorylation combined with Pin1 activity promotes REST degradation in neural progenitors. PMID: 25197063
    5. SCP1 phosphatase substrate specificity: CdcA3 could be an enzymatic substrate for SCP1. PMID: 24769477
    6. Captured the phosphoryl-aspartate intermediate in the crystal structure of a Scp1D206A mutant soaked with para-nitrophenyl phosphate (pNPP), providing strong evidence for the proposed mechanism. PMID: 20222012
    7. Polymorphisms vary significantly between races; Not associated with TB susceptibility in Caucasians. PMID: 11950066
    8. SCP1 may play a role in the regulation of gene expression, possibly by controlling the transition from initiation/capping to processive transcript elongation PMID: 12721286
    9. results show that REST/NRSF recruits SCPs to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells PMID: 15681389
    10. SCP1 acts as a phosphatase for regulatory phosphorylations in the linker region of Smad1 and Smad2. PMID: 17085434

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  • 亚细胞定位：
    Nucleus. Note=Colocalizes with RNA polymerase II.
  • 组织特异性：
    Expression is restricted to non-neuronal tissues. Highest expression in skeletal muscle, spleen, lung and placenta.
  • 数据库链接：

    HGNC: 21614

    OMIM: 605323

    KEGG: hsa:58190

    STRING: 9606.ENSP00000273062

    UniGene: Hs.444468