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CSTF2 Antibody

  • 货号：
    CSB-PA092943
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from 293 cells. HepG2 cells and Jurkat cells, using CSTF2 antibody.
    • Immunofluorescence analysis of HeLa cells, using CSTF2 antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CSTF2 Polyclonal antibody
  • Uniprot No.：
    P33240
  • 基因名：
    CSTF2
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from N-terminal of Human CSTF2.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. This subunit is directly involved in the binding to pre-mRNAs.
  • 基因功能参考文献：
    1. hnRNP H binds to two specific G-runs in exon 5a of ACHE and activates the distal alternative 3 splice site (ss) between exons 5a and 5b. Furthermore, hnRNP H competes for binding of CstF64 to the overlapping binding sites in exon 5a, and suppresses the selection of a cryptic polyadenylation site, which additionally ensures transcription of the distal 3 ss required for the generation of AChET isoform. PMID: 28180311
    2. CstF-64 is dispensable for the expression/3'-end processing of Star-PAP target mRNAs.CstF-64 and 3'-UTR cis-element determine Star-PAP specificity for target mRNA selection by excluding poly A polymerase. PMID: 26496945
    3. CstF64, an essential polyadenylation factor, is a master regulator of 3'-UTR shortening across multiple tumour types. PMID: 25409906
    4. CstF64 is central to the function of a heat-labile factor, composed of cleavage/polyadenylation specificity factor, symplekin, and cleavage stimulation factor 64 and appears to be at least partly responsible for its cell cycle regulation. PMID: 25266659
    5. CstF64 and CstF64tau modulate one another's expression and play overlapping as well as distinct roles in regulating global alternative polyadenylation profiles. PMID: 24149845
    6. CstF64 binds to thousands of dormant intronic PASs that are suppressed, at least in part, by U1 small nuclear ribonucleoproteins PMID: 23112178
    7. CSTF2 is likely to play an important role in lung carcinogenesis and be a prognostic biomarker in the clinic. PMID: 21813631
    8. nuclear accumulation of CstF-64 depends on binding to CstF-77 not symplekin; interaction between CstF-64/CstF-64Tau and CstF-77 are important for maintenance of nuclear levels of CstF complex components and intracellular localization, stability, function PMID: 21119002
    9. The Hinge domain is necessary for CstF-64 interaction with CstF-77 and consequent nuclear localization. PMID: 19887456
    10. dynamics of the CstF-64 RNA-binding domain, both free and bound to two GU-rich RNA sequences that represent polyadenylation regulatory elements, by NMR Spectroscopy PMID: 15769465
    11. The inactivity of the RSV poly(A) site was at least in part due to poor CstF binding since tethering CstF to the RSV substrate activated polyadenylation. PMID: 18272196
    12. CstF64 (cstf2) and not other CstF subunits induced by lipopolysaccharide (LPS) in murine macrophages and changes polyA site use PMID: 16207706
    13. Describes the induction of CSTF2 in the growth phase of cells. PMID: 9736695

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  • 亚细胞定位：
    Nucleus. Note=Localized with DDX1 in cleavage bodies.
  • 数据库链接：

    HGNC: 2484

    OMIM: 300907

    KEGG: hsa:1478

    STRING: 9606.ENSP00000362063

    UniGene: Hs.132370