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CRNN Antibody

  • 货号：
    CSB-PA005988GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9UBG3
  • 基因名：
    CRNN
  • 别名：
    53 kDa putative calcium binding protein antibody; 53 kDa putative calcium-binding protein antibody; 53 kDa squamous epithelial induced stress protein antibody; 53 kDa squamous epithelial-induced stress protein antibody; 58 kDa heat shock protein antibody; C1orf10 antibody; Chromosome 1 open reading frame 10 antibody; Cornulin antibody; CRNN antibody; CRNN_HUMAN antibody; DRC1 antibody; PDRC1 antibody; SEP53 antibody; Squamous epithelial heat shock protein 53 antibody; Tumor related protein antibody; Tumor-related protein antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Human CRNN
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1. Regulates proliferation induced by proinflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways.
  • 基因功能参考文献：
    1. This study showed a significant correlation between LOH/MSI at 1q21.3 with clinical outcomes and that downregulation of CRNN gene could be considered as a prognostic marker of OSCC. PMID: 25846277
    2. The single-nucleotide polymorphisms of CRNN (rs941934) and RPTN (rs3001978, rs28441202) may contribute to Atopic Dermatitis development, but further studies on a larger group of Atopic Dermatitis patients are needed to verify this assumption. PMID: 28219068
    3. Loss of CRNN expression correlated with advanced tumor length, greater tumor invasion depth, lymph node metastasis, and poor survival in patients with esophageal squamous cell carcinoma. PMID: 24263008
    4. Findings demonstrate that CRNN is a tumor suppressor gene that plays a critical tumor suppressive role in ESCC. PMID: 23894350
    5. cornulin is an important molecule in normal esophageal pathology and is likely lost during the conversion of normal to neoplastic epithelium PMID: 22560086
    6. SEP53 may be a component of the mucosal/epithelial innate immune response engaged in an ongoing interaction with a pathogen PMID: 17925851
    7. Results describe the cloning of porcine SEP53, its homology to the human protein, and its expression in the esophagus and in gastric squamous epithelium. PMID: 18465210
    8. CRNN mRNA expression is decreased in eczematous skin PMID: 19133922

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  • 亚细胞定位：
    Cytoplasm. Note=Does not colocalize with TGM1.
  • 蛋白家族：
    S100-fused protein family
  • 组织特异性：
    Expressed in the basal skin layer (at protein level). Squamous epithelia cell-specific. Expressed in the esophagus (periphery of the cells of the granular and the upper spinous layers), foreskin (granular and lower cornified cells), scalp skin (granular l
  • 数据库链接：

    HGNC: 1230

    OMIM: 611312

    KEGG: hsa:49860

    STRING: 9606.ENSP00000271835

    UniGene: Hs.242057