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CRISPLD2 Antibody

  • 货号：
    CSB-PA884430LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CRISPLD2 antibody at 2μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: CEM whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 56, 52, 43, 18, 14 kDa
      Observed band size: 56 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CRISPLD2 Polyclonal antibody
  • Uniprot No.：
    Q9H0B8
  • 基因名：
    CRISPLD2
  • 别名：
    CRISP-11 antibody; CRISP11 antibody; Crispld2 antibody; CRLD2_HUMAN antibody; Cysteine-rich secretory protein 11 antibody; Cysteine-rich secretory protein LCCL domain-containing 2 antibody; DKFZP434B044 antibody; LCCL domain-containing cysteine-rich secretory protein 2 antibody; LCRISP2 antibody; MGC74865 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cysteine-rich secretory protein LCCL domain-containing 2 protein (40-305AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CRISPLD2 Antibody (CSB-PA884430LA01HU)，的标记方式是Non-conjugated。对于CRISPLD2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA884430LB01HU CRISPLD2 Antibody, HRP conjugated ELISA
    FITC CSB-PA884430LC01HU CRISPLD2 Antibody, FITC conjugated
    Biotin CSB-PA884430LD01HU CRISPLD2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Promotes matrix assembly.
  • 基因功能参考文献：
    1. Our results suggest that CRISPLD2 rs4783099 may represent a risk factor for NSCPO (non-syndromic oral clefts). PMID: 27328068
    2. Data suggest that suppression of CRISPLD2 increases the risk of lung inflammation in early life and adulthood. PMID: 27597766
    3. Our data suggest that CRISPLD2 may have a unique anti-HMGB1 effect via miRNA155 and play an important role in immune balance. PMID: 26624800
    4. CRISPLD2 is a target of progesterone receptor and its expression is decreased in women with endometriosis. PMID: 24955763
    5. Results demonstrate genetic polymorphism of CRISPLD2 gene is associated with an increased risk of non-syndromic cleft lip with or without cleft palate. PMID: 25496823
    6. findings define a role for LGL1 in fibroblast expansion and migration, epithelial cell migration, and mesenchymal-epithelial signaling, key processes in fetal lung development. PMID: 25480331
    7. results support the hypothesis that variants in the CRISPLD2 gene may be involved in the etiology of NS CL(P). PMID: 20815724
    8. Both LCCL-domains of human CRISPLD2 have high affinity for lipid A. PMID: 24090571
    9. There is a decreased expression of CRISPLD2 in septic shock and it is association with procalcitonin in sepsis. PMID: 23799041
    10. CRISPLD2 gene contributes to the etiology of NSCLP in the Northwestern Chinese population. SNP rs1546124 is significantly related to NSCLP, associated with both CL/P and CPO groups, and SNP rs4783099 is significantly associated with CPO. PMID: 21800413
    11. the present investigation did not support the hypothesis of the involvement of CRISPLD2 in nonsyndromic cleft lip and palate PMID: 21244519
    12. three SNPs in northern Chinese population found an association between these polymorphisms and NSCLP in both single-marker and haplotype analyses. data further strengthen the conclusion that altered CRISPLD2 is associated with NSCLP susceptibility. PMID: 20662919
    13. CRISPLD2 is expressed in the mandible, palate and nasopharynx regions during craniofacial development at E13.5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP. PMID: 17616516
    14. present work introduces mammal CRISPLD2 as a major serum protein that acts as a natural LPS antagonist and promises to be of considerable preventative value against endotoxic shock. PMID: 19864597

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    CRISP family
  • 数据库链接：

    HGNC: 25248

    OMIM: 612434

    KEGG: hsa:83716

    STRING: 9606.ENSP00000262424

    UniGene: Hs.513779