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CRISP3 Antibody

  • 货号：
    CSB-PA951162
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA951162(CRISP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA951162(CRISP3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P54108
  • 基因名：
    CRISP3
  • 别名：
    Aeg 2 antibody; Aeg2 antibody; CRIS3_HUMAN antibody; CRISP 3 antibody; CRISP-3 antibody; Crisp3 antibody; CRS 3 antibody; CRS3 antibody; Cysteine rich secretory protein 3 antibody; Cysteine-rich secretory protein 3 antibody; dJ442L6.3 antibody; MGC126588 antibody; OTTHUMP00000016590 antibody; OTTHUMP00000039911 antibody; SGP 28 antibody; SGP28 antibody; SGP28 protein antibody; Specific granule protein (28 kDa) antibody; Specific granule protein of 28 kDa antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CRISP3
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. results suggest that overexpression of CRISP-3 in prostate tumor may maintain higher PSA expression and lower ANXA1 expression PMID: 26369530
    2. These data suggest roles for epithelial and neutrophil-derived CRISP3 in postmenstrual endometrial repair and regeneration PMID: 25715794
    3. up-regulation of the mRNA encoding cysteine-rich secretory protein 3 (CRISP3), a glycoprotein with unknown function that is secreted from multiple exocrine glands, was correlated with HCV resistance. PMID: 24978310
    4. Strong CRISP3 expression is associated with unfavorable tumor phenotype and early recurrence in prostate cancers PMID: 23196798
    5. terminal beta-strands of PSP94 contact the first alpha-helix and the hinge region of CRISP-3 PMID: 23375721
    6. MSMB and CRISP3 were widely distributed in ovaries and in ovarian tumors; the expression of MSMB fits well with a tumor-suppressor function in ovarian carcinogenesis. PMID: 22993349
    7. up-regulation of CRISP3 is associated with prostate carcinomas with the TMPRSS2-ERG fusion gene. PMID: 21814574
    8. We found no correlation between CRISP3 expression and biochemical recurrence. PMID: 21240253
    9. Expression levels of AR and CRISP3 were not affected by short-term ADT but were high in castration-resistant prostate cancer (CRPC) and metastases. PMID: 20680031
    10. Either PSP94 or CRISP-3 alone can induce growth inhibition in prostate cancer cells in a cell line specific manner. PMID: 20676114
    11. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
    12. Complex binding of CRISP proteins by A1BG and other proteins may interfere with the detection and function of these proteins. PMID: 20116414
    13. The presence of CRISP-3 in peroxidase-negative granules of neutrophils, in granules of eosinophils, and in exocrine secretions indicates a role in the innate host defense. PMID: 12223513
    14. in situ hybridization experiments indicated that CRISP-3 mRNA is epithelial-specific and is up-regulated in prostate adenocarcinoma compared with benign prostate tissue; a potential biomarker for prostate cancer PMID: 12433721
    15. high levels of CRISP-3 in acinar cells dedifferentiating into small proliferating ductal cells in chronic pancreatitis suggests a role of this molecule in the pathophysiology of chronic pancreatitis PMID: 12647793
    16. alpha-1-B glycoprotein-CRISP-3 complex displays a similar function in protecting the circulation from a potentially harmful effect of free CRISP-3 PMID: 15461460
    17. Human CRISP-3 is a quantitatively minor seminal plasma protein not associated with prostasomes. CRISP-3 was found in secretory epithelium throughout the male genital tract, with particularly high expression in cauda epididymis and ampulla vas deferens. PMID: 15867000
    18. Structural similarity with an MSP-binding protein from blood plasma suggests that CRISP-3 binds MSP through its aminoterminal SCP-domain. PMID: 15950934
    19. Strong immunostaining for CRISP-3 is common in high-grade prostatic-intraepithelial-neoplasia and preserved in prostatic csncer. PMID: 16388501
    20. Predictor of recurrence after radical prostatectomy for localized prostate cancer. PMID: 17634540
    21. CRISP-3 pathology occurred in acini remote from lymphocyte foci and may represent some systemic effect in Sjogren Syndrome. PMID: 17665393
    22. A tentative structure for the hMSP-CRISP-3 complex using the known crystal structure of triflin as a model of CRISP-3 was presented. PMID: 19026612
    23. Results suggest that absence of a local reduction in expression of CRISP-3 in decidualized endometrium of women with EP may be due to reduced exposure to hCG due to the ectopic location of the trophoblast. PMID: 19282327

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  • 亚细胞定位：
    Secreted. Note=In neutrophils, localized in specific granules.
  • 蛋白家族：
    CRISP family
  • 组织特异性：
    Salivary gland, pancreas and prostate > epididymis, ovary, thymus and colon.
  • 数据库链接：

    HGNC: 16904

    KEGG: hsa:10321

    STRING: 9606.ENSP00000389026

    UniGene: Hs.404466