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CRISP2 Antibody

  • 货号：
    CSB-PA005975ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA005975ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CRISP2 Polyclonal antibody
  • Uniprot No.：
    P16562
  • 基因名：
    CRISP2
  • 别名：
    Cancer/testis antigen 36 antibody; CRIS2_HUMAN antibody; CRISP 2 antibody; CRISP-2 antibody; CRISP2 antibody; CT36 antibody; Cysteine rich secretory protein 2 antibody; Cysteine-rich secretory protein 2 antibody; GAPDL5 antibody; Glyceraldehyde 3 phosphate dehydrogenase like 5 antibody; Testis specific protein 1 (probe H4 1 p3 1) antibody; Testis specific protein TPX1 antibody; Testis-specific protein TPX-1 antibody; TPX1 antibody; TSP1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cysteine-rich secretory protein 2 protein (22-243AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate some ion channels' activity and therebye regulate calcium fluxes during sperm capacitation.
  • 基因功能参考文献：
    1. low expression of CRISP2 protein rather than its mRNA was observed in the ejaculated spermatozoa from asthenoteratozoospermic patients as compared with normozoospermic males PMID: 27517483
    2. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm. PMID: 27161017
    3. Crisp2 genetic defects in sperm from humans and mice result in male infertility. PMID: 26786179
    4. Preliminary insight into the mechanism leading to the reduced CRISP2 expression in asthenozoospermia, offering a potential therapeutic target for treating male infertility or for male contraception. PMID: 25505194
    5. Study shows the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Data showed that F-actin is not involved in the relocalization of CRISP2. Found that basic,but not acidic, conditions can solubilize CRISP2 from sperm cells. PMID: 23661501
    6. CRISP2 rescues the phenotype of yeast mutants lacking Pry function and purified CRISP2 binds cholesterol in vitro, indicating that lipid binding is a conserved function of the CAP superfamily proteins. PMID: 23027975
    7. The down-regulation of CRISP2 mRNA and protein expressions in the sperm of asthenospermia patients may be closely related with decreased sperm motility. PMID: 21485539
    8. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included decreased CRISP2&3. PMID: 20625511
    9. TPX1 is a component of the sperm acrosome that remains associated with sperm after capacitation and acrosome reaction , and is relevant for sperm-oocyte interaction. PMID: 15734896
    10. The protein level and localization of TPX1 were altered in patients with spermatogenic arrest and in infertile men with oligoasthenoteratospermia syndrome. PMID: 16759931
    11. Polymorphisms within the CRISP2 gene have no significant association with male infertility. PMID: 18550510

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    CRISP family
  • 组织特异性：
    Testis and epididymis.
  • 数据库链接：

    HGNC: 12024

    OMIM: 187430

    KEGG: hsa:7180

    STRING: 9606.ENSP00000339155

    UniGene: Hs.2042