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  4. CRH Antibody

CRH Antibody

  • 货号：
    CSB-PA257925
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA257925(CRH Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA257925(CRH Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: CSB-PA257925(CRH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds
  • 其他：

产品详情

  • Uniprot No.：
    P06850
  • 基因名：
    CRH
  • 别名：
    CRHCorticoliberin antibody; Corticotropin-releasing factor antibody; CRF antibody; Corticotropin-releasing hormone antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CRH
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile.
  • 基因功能参考文献：
    1. Early-preterm birth showed a syndrome of high maternal CRH and low vitamin D status. PMID: 28780891
    2. REVIEW: CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response PMID: 28260504
    3. REVIEW: Brain and Gut CRF Signaling: Biological Actions and Role in the Gastrointestinal Tract PMID: 28240194
    4. REVIEW: The Multi-faceted Profile of Corticotropin-releasing Factor (CRF) Family of Neuropeptides and of their Receptors on the Paracrine/Local Regulation of the Inflammatory Response PMID: 28103784
    5. Significant effects of CNS sensitization on CRF mRNA levels were detected in the Dorsal Striatum (increasing effect). PMID: 29857328
    6. These results show epigenetic changes in the CRH gene related to severity of suicide attempt in adults and a general psychiatric risk score in adolescents. PMID: 29277323
    7. Data suggest that corticotrophin-releasing hormone (CRH) is able to stimulate copeptin release in healthy controls suggesting direct interaction of CRH/CRH-receptor signaling and vasopressin; these interactions appear to be altered in patients with pituitary disease; copeptin may be serum biomarker of altered CRH/CRH-receptor signaling in pituitary diseases. PMID: 28795329
    8. The development of disorders related to heightened stress sensitivity and dysregulation of stress-coping mechanisms appears to involve regulatory mechanisms of the CRH family members. The purpose of this review is to summarize the most significant discoveries related to CRH over time. [review] PMID: 28071586
    9. A significant increase in CRH and CRHR-1 expression was significantly correlated with psychological stress in vitiligo. PMID: 27663146
    10. Corticotrophin-releasing hormone accelerated tumor angiogenesis by upregulating VEGF expression and secretion in colon cancer cells. PMID: 28618089
    11. This study found that the expressions of CRH and CRHR1 were significantly higher in the epileptogenic tissues of patients with IS than in the control group. PMID: 27534449
    12. The s propose that conditions impacting on epiallele distribution influence the number of transcriptionally active CRH gene copies in the trophoblast cell population determining the gestational trajectory of placental CRH production in normal and pathological pregnancies. PMID: 28151936
    13. Neuroimmune-endocrine events may lead to overactivity of sympathetic nervous system that triggers cascade of pathologic conditions in ovary in polycystic ovary syndrome (PCOS). Data suggest that women with PCOS exhibit reduction of CRH and NGF; reduction of CRH and NGF may be under influence of sympathetic nervous system and may reflect deficit of neuronal stress-adaptation in PCOS patients. (NGF = nerve growth factor) PMID: 27908212
    14. brain activation in response to colorectal distention is enhanced after CRH injection in Irritable bowel syndrome patients compared to healthy controls PMID: 27448273
    15. In deep infiltrating endometriotic lesions, CRH, Ucn and CRH-R2 mRNA levels were significantly higher than in ovarian endometrioma. PMID: 27567427
    16. In summary, cardiac expression of CRFR1, CRF, and Ucn3 genes is elevated in heart failure and may contribute to the activation of the CRF/Ucn system in these patients. PMID: 27754786
    17. VIP and CRF reduce ADAMTS expression and function in osteoarthritis synovial fibroblasts. PMID: 26818776
    18. This study localized a complete CRF system in the human fetal heart. PMID: 27377597
    19. Placenta CRH mRNA concentration appears to convey information about the risk of brain damage in the infant born at an extremely low gestational age. PMID: 26331704
    20. These results suggest that the CRH and CRH-BP genes have no direct effect on Irritable bowel syndrome status. PMID: 26882083
    21. This study evaluated the associations of CRH polymorphisms with susceptibility to MDD and response to antidepressant treatment PMID: 26055202
    22. results suggest that glucocorticoids induce a transcription complex consisting of RelB/p52, CBP, and HDAC1 that triggers a dynamic acetylation-mediated epigenetic change to induce CRH expression in full-term human placenta. PMID: 26307012
    23. Interaction of RelB with the CRH or COX-2 gene promoters decreased when STAT3 was depleted. PMID: 25771405
    24. the present study demonstrates that the expression of CRH/CRH-R1 in lesions of chronic plaque psoriasis is lower than that in psoriatic perilesional skin and normal control skin. PMID: 25630718
    25. results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway PMID: 26350463
    26. This corticotropin releasing factor-induced regulation on norepinephrine transporter expression and function may play a role in development of stress-related depression and anxiety PMID: 26212818
    27. Placental CRH exposure may make a unique contribution to fetal programming of obesity risk. PMID: 25591114
    28. Data suggest that signal transduction involving corticotropin-releasing factor (CRH) and CRH receptors (CRHR) taking place in cochlea are involved in protecting against noise-induced hearing loss. [REVIEW] PMID: 26074267
    29. Production of CRF and UCN1 in human dendritic cells is strongly augmented by commensal intestinal bacteria. PMID: 25339828
    30. we show that Abeta species can hyperexcite CRF neurons, providing a mechanism by which Abeta influences stress-related symptoms PMID: 25673853
    31. High serum corticotropin-releasing hormone (CRH) and bone marrow mast cell CRH receptor expression in a mastocytosis patient. PMID: 24985398
    32. Corticotrophin-Releasing Factor (CRF) and the urocortins are potent regulators of the inflammatory phenotype of human and mouse white adipocytes. PMID: 24835211
    33. Results suggest that ULBP2 is expressed and released from cervical cancer cells by CRF, which regulates NKG2D expression in natural killer cells. PMID: 24841552
    34. This review focuses on the CRF receptor, a stress-related peptide implicated in diverse psychiatric and medical disorders that are more prevalent in females in diverse psychiatric and medical disorders that are more prevalent in females. PMID: 23849813
    35. evidence suggests that CRH regulates neurogenesis in the brain. PMID: 23380766
    36. as labor progresses, progesterone and corticotropin-releasing hormone increase and subsequently decrease precipitously in the immediate postpartal period PMID: 24597258
    37. Data suggest that expression of CRF, CRF-related neuropeptides, and CRF receptors in the liver plays crucial regulatory roles in homeostasis, in allostasis to endogenous stresses, and in adaptation to exogenous stress stimuli. [REVIEW] PMID: 23933692
    38. During the midluteal phase of the cycle, metformin may decrease the production of CRH and urocortin in the endometrium. PMID: 23987517
    39. in human melanoma HMV-II cells both CRF and Ucn1 regulate TRP1 gene expression via Nurr-1/Nur77 production, independent of pro-opiomelanocortin or alpha-melanocyte-stimulating hormone stimulation. PMID: 23416839
    40. IL-6 and CRH are both secreted in a pulsatile fashion during the active phase of human labor. The time-integrated concentrations of the two hormones are positively correlated, with IL-6 leading CRH secretion. PMID: 23928667
    41. ERK1/2 activation in response to CRH is biphasic, involving a first cAMP- and B-Raf-dependent early phase and a second phase that critically depends on CRHR1 internalization and beta-arrestin2. PMID: 23371389
    42. corticotrophin-releasing hormone (CRH) might play a significant role in the pathogenesis of intrahepatic cholestasis of pregnancy(ICP) and provide a new approach to further investigate the etiology of ICP PMID: 23478074
    43. A novel CRH missense mutation (Pro30Arg) results in reduced levels of protein secretion in the short time thus suggesting that mutated people could present an altered capability to respond immediately to stress agents. PMID: 23593457
    44. CRH/CRHR1 are involved in regulation of PGHS2 (prostaglandin-endoperoxide synthase 2) expression in myometrium before/during labor; these actions appear important in priming myometrium for labor and adaptive responses to inflammatory mediators. PMID: 23666959
    45. Data suggest that CRF plays role in acute postinjury gut dysfunction; CRF is expressed in small bowel of elective/emergency gastrointestinal (GI) surgery patients with concomitant GI dysfunction; plasma CRF correlates with poor gastric emptying. PMID: 23466050
    46. Postnatally stressed adult transgenic mice have decreased hippocampal nectin-3 levels, which could be attenuated by CRHR1 inactivation and mimicked by corticotropin-releasing hormone (CRH) overexpression in forebrain neurons. PMID: 23644483
    47. the age-associated changes in the expression of CRH system components reflect an exaggerated stress response reaction, putting the aged skin continuously in a stress-like situation. PMID: 22533365
    48. CRH may be involved in the pathogenesis of gastric cancer PMID: 23477585
    49. study demonstrates that the HeLa cervical cancer cell line expresses CRH; additionally, CRH was shown to induce FasL expression PMID: 23076876
    50. The aberrant expression of corticotropin-releasing hormone in pre-eclampsia may activate the FasL-positive decidual macrophages, impair the physiological turnover of extravillous trophoblasts, and eventually disturb placentation. PMID: 22763913

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Sauvagine/corticotropin-releasing factor/urotensin I family
  • 组织特异性：
    Produced by the hypothalamus and placenta.
  • 数据库链接：

    HGNC: 2355

    OMIM: 122560

    KEGG: hsa:1392

    STRING: 9606.ENSP00000276571

    UniGene: Hs.75294