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CREBZF Antibody

  • 货号：
    CSB-PA040131
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NS37
  • 基因名：
    CREBZF
  • 别名：
    1110034C16Rik antibody; 6330417B10Rik antibody; AI225749 antibody; AI606244 antibody; CREB/ATF bZIP transcription factor antibody; Crebzf antibody; FLJ94018 antibody; HCF-binding transcription factor Zhangfei antibody; Host cell factor-binding transcription factor Zhangfei antibody; LAZip antibody; LAZipII antibody; SHP-interacting leucine zipper protein antibody; SMILE antibody; ZF antibody; ZHANG_HUMAN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Zhangfei.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells.
  • 基因功能参考文献：
    1. Zhangfei/CREBZF stabilizes p53 and co-localizes with it in cellular nuclei; the bLZip domain of Zhangfei is required for its profound effects on cell growth and interaction with p53. PMID: 24200963
    2. Zhangfei had a suppressive effect on most unfolded protein response genes. PMID: 24155933
    3. Results indicate that Ursodeoxycholic acid (UDCA) activates SMILE gene expression, which leads to repression of liver X receptor alpha (LXRalpha)-mediated hepatic lipogenic enzyme gene expression. PMID: 24265317
    4. Our objective was to determine the molecular mechanisms by which Zhangfei influences medulloblastoma cell lines PMID: 22798206
    5. The transcription factor CREBZF is a novel positive regulator of p53. PMID: 22983008
    6. CREBZF, a novel Smad8-binding protein. PMID: 22707059
    7. a microarray study of SMILE knock-down and PMA activation in HeLa cells was compared to earlier analysis based on microarray data of kidney allograft tolerance and rejection to determine possible new genes and gene networks involved in kidney transplantation PMID: 22134986
    8. the curcumin/LKB1/AMPK/SMILE/PGC1alpha pathway differentially regulates ER stress-mediated gene transcription PMID: 21994947
    9. SMILE is involved in the endoplasmic reticulum stress response, by modulating proteasome activity and XBP-1 transcript expression. This function of SMILE may influence immune cell behavior in the context of transplantation. PMID: 21603654
    10. These results indicate that SMILE isoforms regulate the inhibition of estrogen receptor transactivation by SHP in a cell-type-specific manner and act as a novel transcriptional co-regulator in ER signalling. PMID: 18657049
    11. findings showed Zhangfei activated the expression of trkA and Egr1 in medulloblastoma cells and caused these cells to display markers of apoptosis PMID: 18719857
    12. SMILE is a novel corepressor of ERRgamma, and SIRT1 has a role as a novel repressive mechanism for SMILE and ERRgamma inverse agonist PMID: 19690166
    13. ZF suppresses the ability of Luman/CREB3 to activate gene expression PMID: 15705566
    14. ZF suppresses the ability of VP16 to activate herpes simplex virus IE gene expression PMID: 16282471
    15. ZF binds ATF4/CREB2 and enhances its response to MEK1 activation. PMID: 16343488
    16. Zhangfei causes medulloblastoma cells to undergo apoptosis PMID: 18719857
    17. In differentiated PC12 cells, Zhangfei activated the trkA promoter and induced the expression of endogenous trkA. PMID: 19016376

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  • 亚细胞定位：
    Nucleus. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    In adults, expressed most abundantly in heart, liver and skeletal muscle, moderately abundant in kidney and pancreas, and barely detectable in lung. In fetal tissues, expressed most abundantly in kidney and very low amounts in heart, lung and liver.
  • 数据库链接：

    HGNC: 24905

    OMIM: 606444

    KEGG: hsa:58487

    STRING: 9606.ENSP00000433459

    UniGene: Hs.535319