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CREB3L3 Antibody

  • 货号：
    CSB-PA912582
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q68CJ9
  • 基因名：
  • 别名：
    Cyclic AMP-responsive element-binding protein 3-like protein 3, cAMP-responsive element-binding protein 3-like protein 3, Transcription factor CREB-H, Processed cyclic AMP-responsive element-binding protein 3-like protein 3, CREB3L3, CREBH, HYST1481
  • 反应种属：
    Human, Mouse, Rat
  • 免疫原：
    Synthesized peptide derived from part region of human protein
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.
  • 基因功能参考文献：
    1. CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. PMID: 29738435
    2. Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H. PMID: 27029215
    3. Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance. PMID: 26427795
    4. CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID: 25428452
    5. Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis PMID: 23957007
    6. Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia. PMID: 22262056
    7. a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH PMID: 21693703
    8. Levels of CREB transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues. PMID: 12039695
    9. analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis PMID: 17875199
    10. findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin promoter PMID: 19679815

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.
  • 数据库链接：

    HGNC: 18855

    OMIM: 611998

    KEGG: hsa:84699

    STRING: 9606.ENSP00000078445

    UniGene: Hs.247744