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CREB3 Antibody

  • 货号：
    CSB-PA005948ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: Cyclic AMP-responsive element-binding protein 3 antibody at 6μg/ml
      Lane 1: Jurkat whole cell lysate
      Lane 2: HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44, 42, 40 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA005948ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005948ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CREB3 Polyclonal antibody
  • Uniprot No.：
    O43889
  • 基因名：
  • 别名：
    CREB3; LZIP; Cyclic AMP-responsive element-binding protein 3; CREB-3; cAMP-responsive element-binding protein 3; Leucine zipper protein; Luman; Transcription factor LZIP-alpha
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cyclic AMP-responsive element-binding protein 3 protein (1-230AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:1000
    IHC 1:20-200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription. Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death. Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration. Associates with chromatin to the HERPUD1 promoter. Also induces transcriptional activation of chemokine receptors.; This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target genes during endoplasmic reticulum (ER) stress response. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGTFunctions as a negative transcriptional regulator in ligand-induced transcriptional activation of the glucocorticoid receptor NR3C1 by recruiting and activating histone deacetylases (HDAC1, HDAC2 and HDAC6). Also decreases the acetylation level of histone H4. Does not promote the chemotactic activity of leukocyte cells.; (Microbial infection) Plays a role in human immunodeficiency virus type 1 (HIV-1) virus protein expression.; (Microbial infection) Plays a role in herpes simplex virus-1 (HSV-1) latent infection and reactivation from latency. Represses the VP16-mediated transactivation of immediate early genes of the HSV-1 virus by sequestering host cell factor-1 HCFC1 in the ER membrane of sensory neurons, thereby preventing the initiation of the replicative cascade leading to latent infection.; (Microbial infection) May play a role as a cellular tumor suppressor that is targeted by the hepatitis C virus (HCV) core protein.; (Microbial infection) Activates transcription of genes required for reactivation of the latent HSV-1 virus. It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator protein VP16. Binds DNA to the cAMP response element (CRE) (consensus: 5'-GTGACGT(Microbial infection) It's transcriptional activity is inhibited by CREBZF in a HCFC1-dependent manner, by the viral transactivator HCV core protein.
  • 基因功能参考文献：
    1. Luman, a ubiquitous, non-canonical unfolded protein response (UPR), is identified as a novel regulator of endoplasmic reticulum stress-induced PRNP expression. PMID: 28205568
    2. In summary, the s show here that hepatitis C virus infection is associated with an upregulation of ARF4, which promotes hepatitis C virus replication. Upon hepatitis C virus infection, CREB3 was redistributed to nucleus and activated ARF4 transcription. PMID: 28840565
    3. sLZIP is a novel co-repressor of ERalpha, and plays a negative role in ERalpha-mediated cell proliferation in breast cancer PMID: 28662179
    4. These findings indicate that LZIP is a novel modulator of APOA4 expression and hepatic lipid metabolism. PMID: 28246167
    5. The s found that the CREB3/Herp pathway limited the increase in cytosolic Ca2+ concentration and apoptosis early in poliovirus infection and this may reduce the extent of poliovirus-induced damage to the central nervous system during poliomyelitis. PMID: 27405867
    6. The essential parts of the Golgi stress response from the perspective of the organelle autoregulation. The pathways of the mammalian Golgi stress response have been identified, specifically the CREB3 pathway. PMID: 28179603
    7. These results indicate that sLZIP plays a role in expression of c-Jun, and migration and invasion of cervical cancer cells via regulation of MMP-9 transcription. PMID: 24481121
    8. INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. PMID: 25358080
    9. Findings indicate that sLZIP negatively regulates AR transactivation in androgen-dependent PCa cells and functions as a positive regulator in tumor progression of androgen-independent PCa. sLZIP contributes to the malignant phenotype of PCa. PMID: 24441043
    10. human sLZIP plays a critical role in development of atherosclerosis and can be used as a therapeutic target molecule for treatment of atherosclerosis PMID: 25077563
    11. A CREB3-ARF4 signalling cascade may be part of a Golgi stress response set in motion by stimuli compromising Golgi capacity. PMID: 24185178
    12. propose that JAB1 is a novel binding partner of Luman, which negatively regulates the activity of Luman by promoting its degradation PMID: 23583719
    13. GSK3beta was downregulate in all samples and CREB3 did not show a significant decrease or increase in its mRNA expression, but the results were significant in mucoepidermoid carcinoma and salivary duct carcinoma. PMID: 23023215
    14. sLZIP plays a critical role in MMP-9 expression and is probably involved in invasion and metastasis of cervical cancer PMID: 22009750
    15. sLZIP-regulated ARF4 expression in response to phorbol 12-myristate 13-acetate is involved in breast cancer cell migration. PMID: 22004728
    16. These findings suggest that HDAC3 selectively represses CREB3-mediated transcriptional activation and chemotactic signalling in human metastatic breast cancer cells. PMID: 20473547
    17. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. PMID: 20546900
    18. sLZIP functions as a negative regulator in glucocorticoid-induced transcriptional activation of GR by recruitment and activation of HDACs PMID: 19779205
    19. Data show that Luman is processed by regulated intramembrane proteolysis. The site 1 protease (S1P), a Golgi-resident enzyme, may be involved in the processing of Luman. PMID: 12138176
    20. HCF-1 contains an activation domain (HCF-1(AD)) required for maximal transactivation by VP16 and its cellular counterpart LZIP. PMID: 12271126
    21. LZIP binds to CCR1 and the interaction between CCR1 and LZIP participates in regulation of Lkn-1-dependent cell migration without affecting the chemotactic activities of other CC chemokines that bind to CCR1. PMID: 15001559
    22. the host cell factor-binding transcription factor Luman is inhibited by Zhangfei PMID: 15705566
    23. Results report the identification of Herp, a gene involved in ER stress-associated protein degradation (ERAD), as a direct target of Luman. PMID: 16940180
    24. LZIP functions as a positive regulator in the NF-kappaB activation pathway that is triggered by Lkn-1 without affecting the transcriptional activation of NF-kappaB induced by other CCR1-dependent chemokines PMID: 17192849
    25. factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1 PMID: 17296613
    26. Luman/CREB3 recruitment factor inhibits Luman activation of the unfolded protein response PMID: 18391022

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  • 亚细胞定位：
    [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus.; [Isoform 2]: Nucleus. Cytoplasm.; [Processed cyclic AMP-responsive element-binding protein 3]: Nucleus.; [Isoform 1]: Cytoplasm.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    Ubiquitously expressed. Expressed in dendritic cells (DC). Weakly expressed in monocytes (at protein level).
  • 数据库链接：

    HGNC: 2347

    OMIM: 606443

    KEGG: hsa:10488

    UniGene: Hs.522110