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CRAT Antibody

  • 货号：
    CSB-PA14169A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA14169A0Rb at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA14169A0Rb at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CRAT Polyclonal antibody
  • Uniprot No.：
    P43155
  • 基因名：
    CRAT
  • 别名：
    CACP_HUMAN antibody; Carnitine acetylase antibody; Carnitine acetyltransferase antibody; Carnitine O acetyltransferase antibody; Carnitine O-acetyltransferase antibody; CAT antibody; CAT1 antibody; CrAT antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Carnitine O-acetyltransferase protein (181-346AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CRAT Antibody (CSB-PA14169A0Rb)，的标记方式是Non-conjugated。对于CRAT Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA14169B0Rb CRAT Antibody, HRP conjugated ELISA
    FITC CSB-PA14169C0Rb CRAT Antibody, FITC conjugated
    Biotin CSB-PA14169D0Rb CRAT Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the reversible transfer of acyl groups from carnitine to coenzyme A (CoA) and regulates the acyl-CoA/CoA ratio. Also plays a crucial role in the transport of fatty acids for beta-oxidation. Responsible for the synthesis of short- and branched-chain acylcarnitines. Active towards some branched-chain amino acid oxidation pathway (BCAAO) intermediates. Trans-2-enoyl-CoAs and 2-methylacyl-CoAs are poor substrates.
  • 基因功能参考文献：
    1. CrAT turned out to be active towards some but not all the BCAAO intermediates tested and no activity was found with dicarboxylic acyl-CoA esters. PMID: 23485643
    2. the purification, crystallization and preliminary X-ray crystallographic studies of human carnitine acetyltransferase are reported PMID: 12077440
    3. The structure and reactions of this enzyme are examined. PMID: 12562770
    4. structure of a binary complex of human peroxisomal carnitine acetyltransferase and the substrate l-carnitine, refined to a resolution of 1.8; site-directed mutagenesis and kinetic characterization PMID: 15099582
    5. Data show that CrAT overexpression in primary human skeletal myocytes increased glucose uptake and attenuated lipid-induced suppression of glucose oxidation. PMID: 19553674
    6. Human CPT1A, CPT1B, CPT2, CROT and CRAT are known to encode active carnitine acyltransferases. Earlier pfam annotations refer to the non-existing compound CARNITATE. In 2000 this has been changed to CARNITINE. PMID: 11001805

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  • 亚细胞定位：
    Endoplasmic reticulum. Peroxisome. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.; [Isoform 1]: Mitochondrion.; [Isoform 2]: Peroxisome.
  • 蛋白家族：
    Carnitine/choline acetyltransferase family
  • 组织特异性：
    Mostly in skeletal muscle, less in heart, liver and pancreas, only weakly detectable in brain, placenta, lung and kidney.
  • 数据库链接：

    HGNC: 2342

    OMIM: 600184

    STRING: 9606.ENSP00000315013

    UniGene: Hs.12068